Information Analysis for 3D SPECT Imaging of Radionuclide Distributions in Attenuating Objects’


Journal Article

The existing communication model of SPECT studies is extended by including the attenuating medium in the communication channel. Based on the extended model, two fundamental theorems are presented to demonstrate the significance of the mutual information in system design and imaging reconstruction. In addition, we present a mutual information formula for SPECT systems to image radionuclide distributions in attenuating objects using single photon emission computed tomography (SPECT) collimators. The formula is, in turn, expressed in terms of the source distribution, attenuation coefficients, and collimator parameters such as collimator thickness, hole size, septal thickness, hole shape factor, and focal length. The polyhedral collimator is employed for our mutual information analysis in this report. Based on imaging surface decomposition, the analysis of the polyhedral collimator is reduced to the analysis of a single-headed collimator for planar imaging. Conventional collimators including parallel and cone beam collimators are used for the analysis of the single-headed collimator. The information loss due to attenuation is evaluated for myocardial imaging using technetium-99m and thalium-201. © 1994 IEEE

Full Text

Duke Authors

Cited Authors

  • Wang, H; Jaszczak, RJ; Coleman, RE

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 1612 - 1619

Electronic International Standard Serial Number (EISSN)

  • 1558-1578

International Standard Serial Number (ISSN)

  • 0018-9499

Digital Object Identifier (DOI)

  • 10.1109/23.322957

Citation Source

  • Scopus