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MR microscopy of lung airways with hyperpolarized 3He.

Publication ,  Journal Article
Chen, XJ; Chawla, MS; Hedlund, LW; Möller, HE; MacFall, JR; Johnson, GA
Published in: Magn Reson Med
January 1998

A technique using hyperpolarized (HP) 3He to image the small airways of the lung by using moderate flip angles and a short scanning period during early inspiration is demonstrated. Flip angles (alpha) ranging from 10-90 degrees were used in guinea pig experiments with scanning during the entire inspiration period. A second series acquired data throughout a short window of the ventilatory cycle with alpha = 45 degrees. The success of the animal studies has motivated implementation of similar imaging techniques in the clinical arena. Human studies involved imaging over the total inspiration period with alpha approximately 10 degrees. The first series of guinea pig experiments demonstrated that larger flip angles (50-90 degrees) destroy the magnetization before it reaches the smaller airways. At moderate flip angles (20-40 degrees), airway branching down to the fourth generation was apparent. Fifth-order branchings were seen in the images of the second series. The trachea down to fourth generation pulmonary airway branching, along with some distal air spaces, was seen in the human lung images.

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Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

January 1998

Volume

39

Issue

1

Start / End Page

79 / 84

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reference Values
  • Pulmonary Gas Exchange
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Microscopy
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes
 

Citation

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Chen, X. J., Chawla, M. S., Hedlund, L. W., Möller, H. E., MacFall, J. R., & Johnson, G. A. (1998). MR microscopy of lung airways with hyperpolarized 3He. Magn Reson Med, 39(1), 79–84. https://doi.org/10.1002/mrm.1910390113
Chen, X. J., M. S. Chawla, L. W. Hedlund, H. E. Möller, J. R. MacFall, and G. A. Johnson. “MR microscopy of lung airways with hyperpolarized 3He.Magn Reson Med 39, no. 1 (January 1998): 79–84. https://doi.org/10.1002/mrm.1910390113.
Chen XJ, Chawla MS, Hedlund LW, Möller HE, MacFall JR, Johnson GA. MR microscopy of lung airways with hyperpolarized 3He. Magn Reson Med. 1998 Jan;39(1):79–84.
Chen, X. J., et al. “MR microscopy of lung airways with hyperpolarized 3He.Magn Reson Med, vol. 39, no. 1, Jan. 1998, pp. 79–84. Pubmed, doi:10.1002/mrm.1910390113.
Chen XJ, Chawla MS, Hedlund LW, Möller HE, MacFall JR, Johnson GA. MR microscopy of lung airways with hyperpolarized 3He. Magn Reson Med. 1998 Jan;39(1):79–84.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

January 1998

Volume

39

Issue

1

Start / End Page

79 / 84

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reference Values
  • Pulmonary Gas Exchange
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Microscopy
  • Male
  • Magnetic Resonance Imaging
  • Lung
  • Isotopes