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MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study.

Publication ,  Journal Article
Vallée, JP; Sostman, HD; MacFall, JR; Wheeler, T; Hedlund, LW; Spritzer, CE; Coleman, RE
Published in: Magn Reson Med
December 1997

K1 (first-order transfer constant from arterial plasma to myocardium for Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI-derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd-DTPA (0.04 mM/kg) with an inversion-prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd-DTPA, according to a model appropriate for short (<1 s) interimage intervals characteristic of cardiac-triggered acquisitions. Before dipyridamole-induced stress, K1 and Vd, obtained from the fit of the MRI-derived perfusion curves, were 6.2 +/- 1.4 (mHz) and 17.5 +/- 4.2%, respectively. After dipyridamole infusion, a K1 increase of a factor of 2.82 +/- 0.72 was measured (P = 0.003). No change was observed in Vd (P = 0.98). These results suggest that the K1 increase after dipyridamole reflects a flow-related effect that can be useful to quantify the MRI-derived perfusion curves.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 1997

Volume

38

Issue

6

Start / End Page

981 / 989

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Stress, Physiological
  • Rest
  • Perfusion
  • Nuclear Medicine & Medical Imaging
  • Models, Theoretical
  • Magnetic Resonance Imaging
  • Heart
  • Gadolinium DTPA
  • Dogs
 

Citation

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Chicago
ICMJE
MLA
NLM
Vallée, J. P., Sostman, H. D., MacFall, J. R., Wheeler, T., Hedlund, L. W., Spritzer, C. E., & Coleman, R. E. (1997). MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study. Magn Reson Med, 38(6), 981–989. https://doi.org/10.1002/mrm.1910380618
Vallée, J. P., H. D. Sostman, J. R. MacFall, T. Wheeler, L. W. Hedlund, C. E. Spritzer, and R. E. Coleman. “MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study.Magn Reson Med 38, no. 6 (December 1997): 981–89. https://doi.org/10.1002/mrm.1910380618.
Vallée JP, Sostman HD, MacFall JR, Wheeler T, Hedlund LW, Spritzer CE, et al. MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study. Magn Reson Med. 1997 Dec;38(6):981–9.
Vallée, J. P., et al. “MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study.Magn Reson Med, vol. 38, no. 6, Dec. 1997, pp. 981–89. Pubmed, doi:10.1002/mrm.1910380618.
Vallée JP, Sostman HD, MacFall JR, Wheeler T, Hedlund LW, Spritzer CE, Coleman RE. MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study. Magn Reson Med. 1997 Dec;38(6):981–989.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

December 1997

Volume

38

Issue

6

Start / End Page

981 / 989

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Stress, Physiological
  • Rest
  • Perfusion
  • Nuclear Medicine & Medical Imaging
  • Models, Theoretical
  • Magnetic Resonance Imaging
  • Heart
  • Gadolinium DTPA
  • Dogs