MRI quantitative myocardial perfusion with compartmental analysis: a rest and stress study.

Journal Article

K1 (first-order transfer constant from arterial plasma to myocardium for Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) were measured in vivo in a canine model (n = 5) using MRI-derived myocardial perfusion curves and a compartmental model. Perfusion curves were obtained after a bolus injection of Gd-DTPA (0.04 mM/kg) with an inversion-prepared fast gradient echo sequence. Myocardium and blood signal intensity were converted to a concentration of Gd-DTPA, according to a model appropriate for short (<1 s) interimage intervals characteristic of cardiac-triggered acquisitions. Before dipyridamole-induced stress, K1 and Vd, obtained from the fit of the MRI-derived perfusion curves, were 6.2 +/- 1.4 (mHz) and 17.5 +/- 4.2%, respectively. After dipyridamole infusion, a K1 increase of a factor of 2.82 +/- 0.72 was measured (P = 0.003). No change was observed in Vd (P = 0.98). These results suggest that the K1 increase after dipyridamole reflects a flow-related effect that can be useful to quantify the MRI-derived perfusion curves.

Full Text

Duke Authors

Cited Authors

  • Vallée, JP; Sostman, HD; MacFall, JR; Wheeler, T; Hedlund, LW; Spritzer, CE; Coleman, RE

Published Date

  • December 1997

Published In

Volume / Issue

  • 38 / 6

Start / End Page

  • 981 - 989

PubMed ID

  • 9402200

International Standard Serial Number (ISSN)

  • 0740-3194

Language

  • eng

Conference Location

  • United States