The use of gradient flow compensation to separate diffusion and microcirculatory flow in MRI.

Journal Article (Journal Article)

This paper describes a new MR imaging technique termed Modified Stejskal Tanner versus Flow Compensation (MST/FC) for the separation of diffusion and microcirculatory flow. The theory behind the sequence is explained, along with a five-component model of microcirculation applicable to any "perfusion" imaging technique. Phantom data is presented showing that (1) diffusion effects can be matched between MST and FC (suggesting the possibility of flow-compensated diffusion imaging), and (2) the technique is a quantitative method of separating diffusion and slow (less than 0.25 mm/s) tortuous flow through a Sephadex column. Furthermore, animal images show the technique to be feasible and quantitative in measuring rat brain microcirculation under normal, vasodilated (hypercarbia), and no-flow (post mortem) conditions.

Full Text

Duke Authors

Cited Authors

  • Maki, JH; MacFall, JR; Johnson, GA

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 95 - 107

PubMed ID

  • 1712421

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910170114


  • eng

Conference Location

  • United States