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The effect of off-resonance radiofrequency pulse saturation on fMRI contrast.

Publication ,  Journal Article
Song, AW; Wolff, SD; Balaban, RS; Jezzard, P
Published in: NMR Biomed
1997

This paper describes the use of off-resonance saturation to further manipulate the blood oxygenation level dependent (BOLD) contrast of fMRI. A customized narrow bandwidth radiofrequency pulse, applied with a range of frequency offsets prior to selection of each slice, was designed and incorporated into a gradient echo EPI sequence. This application takes advantage of the resonance frequency and linewidth differences between the oxygenated and deoxygenated state of blood in human brain during task activation and rest, and is capable of creating an enhancement in the contrast of the BOLD effect. Because of a possible contribution to the signal change from cerebro-spinal fluid, which has a much narrower linewidth and smaller frequency shift compared with the brain tissue, data were also collected using a nulling inversion pulse. The inversion pulse was applied before the off-resonance pulse and data acquisition to eliminate the CSF signal. Functional areas are thus more localized to the brain tissue.

Duke Scholars

Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

1997

Volume

10

Issue

4-5

Start / End Page

208 / 215

Location

England

Related Subject Headings

  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Brain Mapping
  • Brain
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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ICMJE
MLA
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Song, A. W., Wolff, S. D., Balaban, R. S., & Jezzard, P. (1997). The effect of off-resonance radiofrequency pulse saturation on fMRI contrast. NMR Biomed, 10(4–5), 208–215. https://doi.org/10.1002/(sici)1099-1492(199706/08)10:4/5<208::aid-nbm467>3.0.co;2-s
Song, A. W., S. D. Wolff, R. S. Balaban, and P. Jezzard. “The effect of off-resonance radiofrequency pulse saturation on fMRI contrast.NMR Biomed 10, no. 4–5 (1997): 208–15. https://doi.org/10.1002/(sici)1099-1492(199706/08)10:4/5<208::aid-nbm467>3.0.co;2-s.
Song AW, Wolff SD, Balaban RS, Jezzard P. The effect of off-resonance radiofrequency pulse saturation on fMRI contrast. NMR Biomed. 1997;10(4–5):208–15.
Song, A. W., et al. “The effect of off-resonance radiofrequency pulse saturation on fMRI contrast.NMR Biomed, vol. 10, no. 4–5, 1997, pp. 208–15. Pubmed, doi:10.1002/(sici)1099-1492(199706/08)10:4/5<208::aid-nbm467>3.0.co;2-s.
Song AW, Wolff SD, Balaban RS, Jezzard P. The effect of off-resonance radiofrequency pulse saturation on fMRI contrast. NMR Biomed. 1997;10(4–5):208–215.
Journal cover image

Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

1997

Volume

10

Issue

4-5

Start / End Page

208 / 215

Location

England

Related Subject Headings

  • Oxygen
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Brain Mapping
  • Brain
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
  • 0304 Medicinal and Biomolecular Chemistry