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FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET.

Publication ,  Journal Article
Coleman, RE; Laymon, CM; Turkington, TG
Published in: Radiology
March 1999

PURPOSE: To evaluate 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) imaging of simulated lung nodules in a realistic chest phantom by using attenuation-corrected and non-attenuation-corrected 511-keV single photon emission computed tomography (SPECT), camera-based positron emission tomography (PET), and dedicated PET imaging. MATERIALS AND METHODS: Spheres with diameters of 6, 10, 13, and 22 mm were placed in the lungs of an anthropomorphic chest phantom to simulate nodules. The lungs, nodules, chest wall, and mediastinum were filled with fluorine-18 activities based on the average radionuclide concentrations in those structures from analysis of attenuation-corrected dedicated FDG PET scans. The image sets were evaluated visually and quantitatively by using contrast and signal-to-noise ratios. RESULTS: Attenuation correction reduced the artificially high apparent uptake in the lungs, restored the spherical shape to the nodules, and provided an accurate outer body contour with appropriate intensity. Dedicated PET depicted all four nodules, camera-based PET depicted the three largest nodules, and SPECT depicted the two largest nodules. Lesion contrast was better on the attenuation-corrected images than on the non-attenuation-corrected images. The signal-to-noise ratio generally was improved with attenuation correction. CONCLUSION: Attenuation correction results in many changes in the images and improves lesion detection.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

March 1999

Volume

210

Issue

3

Start / End Page

823 / 828

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tomography, Emission-Computed
  • Thorax
  • Signal Processing, Computer-Assisted
  • Radiopharmaceuticals
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mediastinum
  • Lung Diseases
  • Lung
 

Citation

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Coleman, R. E., Laymon, C. M., & Turkington, T. G. (1999). FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET. Radiology, 210(3), 823–828. https://doi.org/10.1148/radiology.210.3.r99mr18823
Coleman, R. E., C. M. Laymon, and T. G. Turkington. “FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET.Radiology 210, no. 3 (March 1999): 823–28. https://doi.org/10.1148/radiology.210.3.r99mr18823.
Coleman RE, Laymon CM, Turkington TG. FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET. Radiology. 1999 Mar;210(3):823–8.
Coleman, R. E., et al. “FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET.Radiology, vol. 210, no. 3, Mar. 1999, pp. 823–28. Pubmed, doi:10.1148/radiology.210.3.r99mr18823.
Coleman RE, Laymon CM, Turkington TG. FDG imaging of lung nodules: a phantom study comparing SPECT, camera-based PET, and dedicated PET. Radiology. 1999 Mar;210(3):823–828.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

March 1999

Volume

210

Issue

3

Start / End Page

823 / 828

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Tomography, Emission-Computed
  • Thorax
  • Signal Processing, Computer-Assisted
  • Radiopharmaceuticals
  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • Mediastinum
  • Lung Diseases
  • Lung