Quantification of myocardial perfusion by MRI after coronary occlusion.
Journal Article (Journal Article)
The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI-derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.
- Vallée, JP; Sostman, HD; MacFall, JR; DeGrado, TR; Zhang, J; Sebbag, L; Cobb, FR; Wheeler, T; Hedlund, LW; Turkington, TG; Spritzer, CE; Coleman, RE
- August 1998
Volume / Issue
- 40 / 2
Start / End Page
- 287 - 297
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States