Skip to main content
Journal cover image

Quantification of myocardial perfusion by MRI after coronary occlusion.

Publication ,  Journal Article
Vallée, JP; Sostman, HD; MacFall, JR; DeGrado, TR; Zhang, J; Sebbag, L; Cobb, FR; Wheeler, T; Hedlund, LW; Turkington, TG; Spritzer, CE; Coleman, RE
Published in: Magn Reson Med
August 1998

The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI-derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

August 1998

Volume

40

Issue

2

Start / End Page

287 / 297

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Gadolinium DTPA
  • Dogs
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vallée, J. P., Sostman, H. D., MacFall, J. R., DeGrado, T. R., Zhang, J., Sebbag, L., … Coleman, R. E. (1998). Quantification of myocardial perfusion by MRI after coronary occlusion. Magn Reson Med, 40(2), 287–297. https://doi.org/10.1002/mrm.1910400215
Vallée, J. P., H. D. Sostman, J. R. MacFall, T. R. DeGrado, J. Zhang, L. Sebbag, F. R. Cobb, et al. “Quantification of myocardial perfusion by MRI after coronary occlusion.Magn Reson Med 40, no. 2 (August 1998): 287–97. https://doi.org/10.1002/mrm.1910400215.
Vallée JP, Sostman HD, MacFall JR, DeGrado TR, Zhang J, Sebbag L, et al. Quantification of myocardial perfusion by MRI after coronary occlusion. Magn Reson Med. 1998 Aug;40(2):287–97.
Vallée, J. P., et al. “Quantification of myocardial perfusion by MRI after coronary occlusion.Magn Reson Med, vol. 40, no. 2, Aug. 1998, pp. 287–97. Pubmed, doi:10.1002/mrm.1910400215.
Vallée JP, Sostman HD, MacFall JR, DeGrado TR, Zhang J, Sebbag L, Cobb FR, Wheeler T, Hedlund LW, Turkington TG, Spritzer CE, Coleman RE. Quantification of myocardial perfusion by MRI after coronary occlusion. Magn Reson Med. 1998 Aug;40(2):287–297.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

August 1998

Volume

40

Issue

2

Start / End Page

287 / 297

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Myocardial Infarction
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Image Enhancement
  • Gadolinium DTPA
  • Dogs