Quantification of myocardial perfusion by MRI after coronary occlusion.

Journal Article (Journal Article)

The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI-derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.

Full Text

Duke Authors

Cited Authors

  • Vallée, JP; Sostman, HD; MacFall, JR; DeGrado, TR; Zhang, J; Sebbag, L; Cobb, FR; Wheeler, T; Hedlund, LW; Turkington, TG; Spritzer, CE; Coleman, RE

Published Date

  • August 1998

Published In

Volume / Issue

  • 40 / 2

Start / End Page

  • 287 - 297

PubMed ID

  • 9702711

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910400215


  • eng

Conference Location

  • United States