Quantitative SPECT Imaging with Indium-1111


Journal Article

The potential of SPECT to quantify the distribution of indium-111 was investigated in an experimental phantom study. Non-uniform attenuation compensation using acquired transmission data was compared to uniform compensation based on reconstructed quantitative accuracy and noise. The reconstructed transmission data provided the attenuation map for the non-uniform compensation. Results showed that nonuniform attenuation compensation improved image quality, quantitative accuracy, and noise compared to uniform compensation. Noise increased with a decrease in counts in the non-uniform attenuation map but remained substantially below the uniform compensation level. The noise effect was observed with both Chang and ML-EM reconstruction methods. Independent reconstruction of the 172 and 247 keV emission data was compared to the reconstruction of the combined 172 and 247 keV projection data. Improved quantitative accuracy and image noise resulted when both In-111 emission energies were used. However, independent reconstruction of the two energies did not substantially improve accuracy or noise compared with the reconstruction of the combined data. © 1991 IEEE

Full Text

Duke Authors

Cited Authors

  • Gilland, DR; Jaszczak, RJ; Turkington, TG; Greer, KL; Coleman, RE

Published Date

  • January 1, 1991

Published In

Volume / Issue

  • 38 / 2

Start / End Page

  • 761 - 766

Electronic International Standard Serial Number (EISSN)

  • 1558-1578

International Standard Serial Number (ISSN)

  • 0018-9499

Digital Object Identifier (DOI)

  • 10.1109/23.289386

Citation Source

  • Scopus