Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.
Journal Article (Journal Article)
A method is described for labeling proteins with 7.2 h half-life 211 At. The alpha particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce 211 At-labeled IgG in 25-40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the 211 At-labeled IgG conjugate is stable in vivo.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Narula, AS
Published Date
- January 1988
Published In
Volume / Issue
- 39 / 3
Start / End Page
- 227 - 232
PubMed ID
- 2836342
International Standard Serial Number (ISSN)
- 0883-2889
Digital Object Identifier (DOI)
- 10.1016/0883-2889(88)90176-1
Language
- eng