Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate.

Journal Article

A method is described for labeling proteins with 7.2 h half-life 211 At. The alpha particle-emitting nuclide was coupled to goat IgG using an N-succinimidyl 3-(tri-n-butylstannyl) benzoate intermediate. The reaction and purification sequence requires about 2 h to produce 211 At-labeled IgG in 25-40% radiochemical yield. Comparative blood clearance measurements in mice suggest that the 211 At-labeled IgG conjugate is stable in vivo.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, MR; Narula, AS

Published Date

  • 1988

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 227 - 232

PubMed ID

  • 2836342

International Standard Serial Number (ISSN)

  • 0883-2889

Language

  • eng

Conference Location

  • England