Evaluation of an internal cyclotron target for the production of 211At via the 209Bi (alpha,2n)211 at reaction.

Journal Article (Journal Article)

Astatine-211 is a 7.2 h half-life alpha-emitting radionuclide which has shown great promise for targeted radiotherapy. It is generally produced by cyclotron bombardment of bismuth metal targets with 28 MeV alpha-particles via the 209Bi(alpha,2n)211 At reaction. In order to provide 211At activity levels anticipated for clinical investigations, an internal target system has been designed and evaluated. The system has a grazing-angle configuration and leading- and trailing-edge monitors. Both aluminum and copper target backings were evaluated. With approx. 28 MeV alpha-particles, the 211At production efficiency was 41 +/- 7 MBq/microA.h, compared with 10.6 +/- 1.2 MBq/microA.h for an external target. Radionuclidic purity of 211At was high with no evidence of 210At.

Full Text

Duke Authors

Cited Authors

  • Larsen, RH; Wieland, BW; Zalutsky, MR

Published Date

  • February 1996

Published In

Volume / Issue

  • 47 / 2

Start / End Page

  • 135 - 143

PubMed ID

  • 8852627

Pubmed Central ID

  • 8852627

International Standard Serial Number (ISSN)

  • 0969-8043

Digital Object Identifier (DOI)

  • 10.1016/0969-8043(95)00285-5


  • eng

Conference Location

  • England