Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics
The thermally-responsive carrier, an elastin-like polypeptide (ELP), is an oligomer of a Val-Pro-Gly-Xaa-Gly pentapeptide repeat. Below a specific, inverse phase transition temperature (Tt), ELPs are highly soluble in aqueous solution. However, upon raising the Tt, they undergo a reversible transition resulting in desolvation and aggregation. Control of the amino acid sequence and the molecular weight of the carrier by genetically encodable synthesis enables precise molecular design of ELPs with an inverse transition of -40 °C. ELP was studied whether it will remain soluble systematically but will accumulate at sites of externally-induced local hyperthermia where the temperature is raised above Tt.
Meyer, DE; Kong, GA; Dewhirst, MW; Foulon, C; Zalutsky, MR; Chilkoti, A
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)