Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates.
Journal Article (Journal Article;Review)
Radionuclides which decay by the emission of alpha-particles are attractive for certain radioimmunotherapeutic applications. These include the treatment of lymphomas, compartmentally spread malignancies such as ovarian cancer and neoplastic meningitis, and micrometastatic disease. Two alpha-emitting radionuclides of interest for this purpose are 212Bi (60.6 min half life) and 211At (7.2 hr half life). Compared with the beta-emitters commonly used for radiotherapy, the alpha-particles of 212Bi and 211At are of higher energy, much shorter range (less than 100 microm), and considerably higher linear energy transfer. Preliminary results obtained in a variety of in vitro systems and in vivo models have documented the exquisite toxicity of alpha-particles and have established a basis for initiating radiotherapy trials in humans with monoclonal antibodies labeled with alpha-emitting radionuclides.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Bigner, DD
Published Date
- 1996
Published In
Volume / Issue
- 35 / 3
Start / End Page
- 373 - 379
PubMed ID
- 8679269
International Standard Serial Number (ISSN)
- 0284-186X
Digital Object Identifier (DOI)
- 10.3109/02841869609101654
Language
- eng
Conference Location
- England