Arterial stiffness measurements with acoustic radiation force impulse imaging


Conference Paper

We have developed a new method of imaging the mechanical properties of tissues based on very brief (< 1msec) and localized applications of acoustic radiation force and the ultrasonic measurement of local tissues' responses to that force. Initial results with this technique demonstrate its ability to image mechanical properties of the medial and adventitial layers within ex vivo and in vivo arteries, and to distinguish hard and soft atherosclerotic plaques from normal vessel wall. We have labeled this method Acoustic Radiation Force Impulse (ARFI) imaging. We describe studies to utilize this technique in the characterization of diffuse and focal atherosclerosis. We describe phantom trials and finite element simulations which explore the fundamental resolution and contrast achievable with this method. We describe in vivo and ex vivo trials in the popliteal, femoral and brachial arteries to assess the relationship between the mechanical properties of healthy and diseased arteries provided by this method and those obtained by alternative methods.

Full Text

Duke Authors

Cited Authors

  • Trahey, GE; Dahl, JJ; McAleavey, SA; Gallippi, CM; Nightingale, KR

Published Date

  • September 12, 2003

Published In

Volume / Issue

  • 5035 /

Start / End Page

  • 235 - 241

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.479966

Citation Source

  • Scopus