Ensuring the operational health of droplet-based microelectrofluidic biosensor systems

Journal Article (Journal Article)

Recent events have heightened the need for fast, accurate, and reliable biological/chemical sensor systems for critical loca tions. As droplet-based microelectrofluidic sensor systems become widespread in these safety-critical biomedical applications, reliability emerges as a critical performance parameter. In order to ensure the operational health of such safety-critical systems, they need to be monitored for defects, not only after manufacturing, but also during in-field operation. In this paper, we present a cost-effective concurrent test methodology for droplet-based microelectrofluidic systems. We present a classification of catastrophic and parametric faults in such systems and show how faults can be detected by electrostatically controlling and tracking droplet motion. We then present a fault simulation approach based on tolerance analysis using Monte-Carlo simulation to characterize the impact of parameter variations on system performance. Finally, we present experimental results on a droplet-based microelectrofluidic system for a real-time polymerase chain reaction application. © 2005 IEEE.

Full Text

Duke Authors

Cited Authors

  • Su, F; Ozev, S; Chakrabarty, K

Published Date

  • August 1, 2005

Published In

Volume / Issue

  • 5 / 4

Start / End Page

  • 763 - 772

International Standard Serial Number (ISSN)

  • 1530-437X

Digital Object Identifier (DOI)

  • 10.1109/JSEN.2005.848127

Citation Source

  • Scopus