Coded aperture Raman spectroscopy for quantitative measurements of ethanol in a tissue phantom.

Published

Journal Article

Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r(2) > 0.98. Leave-one-out cross-validation demonstrates prediction errors of <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

Full Text

Duke Authors

Cited Authors

  • McCain, ST; Gehm, ME; Wang, Y; Pitsianis, NP; Brady, DJ

Published Date

  • June 2006

Published In

Volume / Issue

  • 60 / 6

Start / End Page

  • 663 - 671

PubMed ID

  • 16808868

Pubmed Central ID

  • 16808868

Electronic International Standard Serial Number (EISSN)

  • 1943-3530

International Standard Serial Number (ISSN)

  • 0003-7028

Digital Object Identifier (DOI)

  • 10.1366/000370206777670693

Language

  • eng