S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control.

Journal Article (Journal Article)

A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood cells are oxygenated, and the NO group is released during arterial-venous transit. The vasoactivity of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols. These findings highlight newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure and which may facilitate efficient delivery of oxygen to tissues. The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.

Full Text

Duke Authors

Cited Authors

  • Jia, L; Bonaventura, C; Bonaventura, J; Stamler, JS

Published Date

  • March 1996

Published In

Volume / Issue

  • 380 / 6571

Start / End Page

  • 221 - 226

PubMed ID

  • 8637569

Electronic International Standard Serial Number (EISSN)

  • 1476-4687

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/380221a0


  • eng