Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.

Journal Article (Journal Article)

The goal of these experiments was to explore the relationship between cytochrome P4501A (CYP1A) induction and the teratogenicity of sediments from the Atlantic Wood Industries Superfund site (Elizabeth River, VA) in Fundulus heteroclitus embryos. In these experiments we used embryos spawned from reference site adults to assess CYP1A activity and teratogenicity induced by aqueous Elizabeth River sediment extracts (ERSE). Embryo exposures to ERSE induced CYP1A activity and caused deformities, including pericardial edema, heart elongation and tail shortening. Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein.

Full Text

Duke Authors

Cited Authors

  • Wassenberg, DM; Di Giulio, RT

Published Date

  • August 2004

Published In

Volume / Issue

  • 58 / 2-5

Start / End Page

  • 163 - 168

PubMed ID

  • 15178029

Electronic International Standard Serial Number (EISSN)

  • 1879-0291

International Standard Serial Number (ISSN)

  • 0141-1136

Digital Object Identifier (DOI)

  • 10.1016/j.marenvres.2004.03.012


  • eng