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Safety of rifampin and pyrazinamide for the treatment of latent tuberculosis infection.

Publication ,  Journal Article
Stout, JE
Published in: Expert Opin Drug Saf
May 2004

A 2-month regimen of rifampin and pyrazinamide (2RZ) became an accepted alternative for treatment of latent tuberculosis (TB) after initial studies in HIV-seropositive patients demonstrated safety and efficacy. Once this alternative came into widespread use, however, a number of cases of severe and fatal hepatitis associated with 2RZ were reported. Although the initial experience with HIV-seropositive patients was encouraging, subsequent research demonstrated that the risk of 2RZ-associated hepatitis is considerably greater than the risk of hepatitis associated with isoniazid treatment for latent TB. Updated guidelines now recommend only restricted use of the 2RZ regimen for latent TB, with careful supervision.

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Published In

Expert Opin Drug Saf

DOI

ISSN

1474-0338

Publication Date

May 2004

Volume

3

Issue

3

Start / End Page

187 / 198

Location

England

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Rifampin
  • Randomized Controlled Trials as Topic
  • Pyrazinamide
  • Pharmacology & Pharmacy
  • Isoniazid
  • Humans
  • Drug Therapy, Combination
  • Antitubercular Agents
  • Antibiotics, Antitubercular
 

Citation

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Stout, J. E. (2004). Safety of rifampin and pyrazinamide for the treatment of latent tuberculosis infection. Expert Opin Drug Saf, 3(3), 187–198. https://doi.org/10.1517/eods.3.3.187.31073
Stout, Jason E. “Safety of rifampin and pyrazinamide for the treatment of latent tuberculosis infection.Expert Opin Drug Saf 3, no. 3 (May 2004): 187–98. https://doi.org/10.1517/eods.3.3.187.31073.
Stout, Jason E. “Safety of rifampin and pyrazinamide for the treatment of latent tuberculosis infection.Expert Opin Drug Saf, vol. 3, no. 3, May 2004, pp. 187–98. Pubmed, doi:10.1517/eods.3.3.187.31073.

Published In

Expert Opin Drug Saf

DOI

ISSN

1474-0338

Publication Date

May 2004

Volume

3

Issue

3

Start / End Page

187 / 198

Location

England

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Rifampin
  • Randomized Controlled Trials as Topic
  • Pyrazinamide
  • Pharmacology & Pharmacy
  • Isoniazid
  • Humans
  • Drug Therapy, Combination
  • Antitubercular Agents
  • Antibiotics, Antitubercular