Safety of rifampin and pyrazinamide for the treatment of latent tuberculosis infection.

Journal Article (Journal Article;Review)

A 2-month regimen of rifampin and pyrazinamide (2RZ) became an accepted alternative for treatment of latent tuberculosis (TB) after initial studies in HIV-seropositive patients demonstrated safety and efficacy. Once this alternative came into widespread use, however, a number of cases of severe and fatal hepatitis associated with 2RZ were reported. Although the initial experience with HIV-seropositive patients was encouraging, subsequent research demonstrated that the risk of 2RZ-associated hepatitis is considerably greater than the risk of hepatitis associated with isoniazid treatment for latent TB. Updated guidelines now recommend only restricted use of the 2RZ regimen for latent TB, with careful supervision.

Full Text

Duke Authors

Cited Authors

  • Stout, JE

Published Date

  • May 2004

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 187 - 198

PubMed ID

  • 15155147

International Standard Serial Number (ISSN)

  • 1474-0338

Digital Object Identifier (DOI)

  • 10.1517/eods.


  • eng

Conference Location

  • England