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NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

Publication ,  Journal Article
Zhang, JY; Green, CL; Tao, S; Khavari, PA
Published in: Genes Dev
January 1, 2004
Published version (DOI) Link to item

NF-kappaB inhibition promotes epidermal tumorigenesis; however, whether this reflects an underlying role in homeostasis or a special case confined to neoplasia is unknown. Embryonic lethality of mice lacking NF-kappaB RelA has hindered efforts to address this. We therefore generated developmentally mature RelA(-/-) skin. RelA(-/-) epidermis displays hyperplasia without abnormal differentiation, inflammation, or apoptosis. Hyperproliferation is TNFR1-dependent because Tnfr1 deletion normalized cell division. TNFR1-dependent JNK activation occurred in RelA(-/-) epidermis, and JNK inhibition abolished hyperproliferation due to RelA deficiency. Thus, RelA antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth.

Duke Scholars

Jennifer Yunyan Zhang
Author Jennifer Yunyan Zhang Dermatology

Published In

Genes Dev

DOI

10.1101/gad.1160904

ISSN

0890-9369

Publication Date

January 1, 2004

Volume

18

Issue

1

Start / End Page

17 / 22

Location

United States

Related Subject Headings

  • Transcription Factor RelA
  • Skin
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • NF-kappa B
  • Mice, SCID
  • Mice
  • Keratinocytes
  • Epidermis
  • Epidermal Cells
 

Citation

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Zhang, J. Y., Green, C. L., Tao, S., & Khavari, P. A. (2004). NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev, 18(1), 17–22. https://doi.org/10.1101/gad.1160904
Zhang, Jennifer Y., Cheryl L. Green, Shiying Tao, and Paul A. Khavari. “NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.” Genes Dev 18, no. 1 (January 1, 2004): 17–22. https://doi.org/10.1101/gad.1160904.
Zhang JY, Green CL, Tao S, Khavari PA. NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev. 2004 Jan 1;18(1):17–22.
Zhang, Jennifer Y., et al. “NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.” Genes Dev, vol. 18, no. 1, Jan. 2004, pp. 17–22. Pubmed, doi:10.1101/gad.1160904.
Zhang JY, Green CL, Tao S, Khavari PA. NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK. Genes Dev. 2004 Jan 1;18(1):17–22.

Published In

Genes Dev

DOI

10.1101/gad.1160904

ISSN

0890-9369

Publication Date

January 1, 2004

Volume

18

Issue

1

Start / End Page

17 / 22

Location

United States

Related Subject Headings

  • Transcription Factor RelA
  • Skin
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor
  • NF-kappa B
  • Mice, SCID
  • Mice
  • Keratinocytes
  • Epidermis
  • Epidermal Cells