Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance.


Journal Article

We report the combined use of heliox and high-frequency jet ventilation to augment carbon dioxide clearance, with a focus on the important technical considerations. Our case is a 5-month old infant with acute respiratory failure associated with gas trapping, hypercarbia, respiratory acidosis, and air leak. Despite maximal conventional ventilation, bronchodilator therapy, corticosteroids, and sedation, the infant continued to demonstrate worsening gas exchange necessitating an escalation of support to high-frequency oscillatory ventilation. After the development of an air leak and continued difficulties with carbon dioxide clearance, the patient was transitioned to high-frequency jet ventilation. Persistent hypercarbia resulted in the addition of heliox to facilitate ventilation. Improvements in gas exchange occurred rapidly. The combination of heliox and high frequency jet ventilation resulted in improved carbon dioxide clearance, respiratory stabilization, and the ability to wean ventilator settings.

Full Text

Duke Authors

Cited Authors

  • Gupta, VK; Grayck, EN; Cheifetz, IM

Published Date

  • September 2004

Published In

Volume / Issue

  • 49 / 9

Start / End Page

  • 1038 - 1044

PubMed ID

  • 15329176

Pubmed Central ID

  • 15329176

International Standard Serial Number (ISSN)

  • 0020-1324


  • eng

Conference Location

  • United States