Imprinted genes as potential genetic and epigenetic toxicologic targets.

Published

Journal Article (Review)

Genomic imprinting is an epigenetic phenomenon in eutherian mammals that results in the differential expression of the paternally and maternally inherited alleles of a gene. Imprinted genes are necessary for normal mammalian development. This requirement has been proposed to have evolved because of an interparental genetic battle for the utilization of maternal resources during gestation and postnatally. The nonrandom requisite for monoallelic expression of a subset of genes has also resulted in the formation of susceptibility loci for neurobehavioral disorders, developmental disorders, and cancer. Since imprinting involves both cytosine methylation within CpG islands and changes in chromatin structure, imprinted genes are potential targets for dysregulation by epigenetic toxicants that modify DNA methylation and histone acetylation.

Full Text

Duke Authors

Cited Authors

  • Murphy, SK; Jirtle, RL

Published Date

  • March 2000

Published In

Volume / Issue

  • 108 Suppl 1 /

Start / End Page

  • 5 - 11

PubMed ID

  • 10698719

Pubmed Central ID

  • 10698719

Electronic International Standard Serial Number (EISSN)

  • 1552-9924

International Standard Serial Number (ISSN)

  • 0091-6765

Digital Object Identifier (DOI)

  • 10.1289/ehp.00108s15

Language

  • eng