Prenatal diagnosis using fetal cells from the maternal circulation.
Publication
, Journal Article
Lamvu, G; Kuller, JA
Published in: Obstet Gynecol Surv
July 1997
Current prenatal diagnosis relies on invasive methods such as amniocentesis and chorionic villus sampling. Because these methods carry a low, but finite risk of pregnancy loss, noninvasive genetic screening techniques are the focus of intense research. Isolating fetal cells from maternal blood for genetic analysis is the least invasive method currently being investigated. We discuss the various methods that have been used to isolate these cells. Nucleated red blood cells have emerged as the ideal fetal cell type. This is because they have the DNA material necessary for genetic analysis, they are consistently present in maternal blood, they can be easily identified based on their morphology, and they have a definite gestational life span.
Duke Scholars
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Published In
Obstet Gynecol Surv
DOI
ISSN
0029-7828
Publication Date
July 1997
Volume
52
Issue
7
Start / End Page
433 / 437
Location
United States
Related Subject Headings
- Prenatal Diagnosis
- Pregnancy
- Predictive Value of Tests
- Polymerase Chain Reaction
- Obstetrics & Reproductive Medicine
- Infant, Newborn
- In Situ Hybridization, Fluorescence
- Humans
- Gestational Age
- Genetic Testing
Citation
APA
Chicago
ICMJE
MLA
NLM
Lamvu, G., & Kuller, J. A. (1997). Prenatal diagnosis using fetal cells from the maternal circulation. Obstet Gynecol Surv, 52(7), 433–437. https://doi.org/10.1097/00006254-199707000-00022
Lamvu, G., and J. A. Kuller. “Prenatal diagnosis using fetal cells from the maternal circulation.” Obstet Gynecol Surv 52, no. 7 (July 1997): 433–37. https://doi.org/10.1097/00006254-199707000-00022.
Lamvu G, Kuller JA. Prenatal diagnosis using fetal cells from the maternal circulation. Obstet Gynecol Surv. 1997 Jul;52(7):433–7.
Lamvu, G., and J. A. Kuller. “Prenatal diagnosis using fetal cells from the maternal circulation.” Obstet Gynecol Surv, vol. 52, no. 7, July 1997, pp. 433–37. Pubmed, doi:10.1097/00006254-199707000-00022.
Lamvu G, Kuller JA. Prenatal diagnosis using fetal cells from the maternal circulation. Obstet Gynecol Surv. 1997 Jul;52(7):433–437.
Published In
Obstet Gynecol Surv
DOI
ISSN
0029-7828
Publication Date
July 1997
Volume
52
Issue
7
Start / End Page
433 / 437
Location
United States
Related Subject Headings
- Prenatal Diagnosis
- Pregnancy
- Predictive Value of Tests
- Polymerase Chain Reaction
- Obstetrics & Reproductive Medicine
- Infant, Newborn
- In Situ Hybridization, Fluorescence
- Humans
- Gestational Age
- Genetic Testing