Prenatal diagnosis using fetal cells from the maternal circulation.

Journal Article (Journal Article;Review)

Current prenatal diagnosis relies on invasive methods such as amniocentesis and chorionic villus sampling. Because these methods carry a low, but finite risk of pregnancy loss, noninvasive genetic screening techniques are the focus of intense research. Isolating fetal cells from maternal blood for genetic analysis is the least invasive method currently being investigated. We discuss the various methods that have been used to isolate these cells. Nucleated red blood cells have emerged as the ideal fetal cell type. This is because they have the DNA material necessary for genetic analysis, they are consistently present in maternal blood, they can be easily identified based on their morphology, and they have a definite gestational life span.

Full Text

Duke Authors

Cited Authors

  • Lamvu, G; Kuller, JA

Published Date

  • July 1997

Published In

Volume / Issue

  • 52 / 7

Start / End Page

  • 433 - 437

PubMed ID

  • 9219277

International Standard Serial Number (ISSN)

  • 0029-7828

Digital Object Identifier (DOI)

  • 10.1097/00006254-199707000-00022


  • eng

Conference Location

  • United States