Contemporary approaches to prenatal diagnosis.

Published

Journal Article

A variety of options for prenatal diagnosis are available to the pregnant woman. Maternal serum analyte analysis, performed between 15 and 20 weeks' gestation, provides a screening test for fetal neural tube defects and aneuploidy in low-risk pregnancies. Fetal ultrasound examination is of benefit in high-risk pregnancies. The necessity of prenatal screening in the low-risk patient with an established date of last menstrual period is more controversial. Ultrasound examination can establish gestational age, assess fetal number and position, determine placental location and amniotic fluid volume, and rule out major structural anomalies. Invasive fetal testing, including amniocentesis and chorionic villus sampling, should be offered to women who are 35 years of age or older or who have had abnormal results on noninvasive prenatal screening and in cases in which the parents are carriers of genetic conditions that are amenable to prenatal diagnosis.

Full Text

Duke Authors

Cited Authors

  • Kuller, JA; Laifer, SA

Published Date

  • December 1995

Published In

Volume / Issue

  • 52 / 8

Start / End Page

  • 2277 - 2286

PubMed ID

  • 7484721

Pubmed Central ID

  • 7484721

International Standard Serial Number (ISSN)

  • 0002-838X

Language

  • eng

Conference Location

  • United States