Alpha 1-antitrypsin deficiency and pregnancy.
Alpha1-antitrypsin deficiency is an inherited pulmonary disorder which results from a deficiency of a major plasma protease inhibitor. The onset and severity of symptoms vary widely and depend on the genotype and whether the patient smokes cigarettes. Alpha1-antitrypsin in pregnancy has only been previously reported twice. Our patient had a functional serum alpha1-antitrypsin level which was 15% of normal but was clinically asymptomatic and she did not smoke. Her genotype revealed a non-ZZ pattern. Her obstetric history was complicated by preterm labor in each of her five ongoing pregnancies. Alpha1-antitrypsin deficiency is inherited via two codominant autosomal genes. Although there is great variability in severity of disease, seriously affected patients may have emphysema and hepatic abnormalities. Patients with non-ZZ genotypes or who are heterozygotes may have favorable pregnancy outcomes.
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- alpha 1-Antitrypsin Deficiency
- alpha 1-Antitrypsin
- Pregnancy Complications
- Pregnancy
- Obstetrics & Reproductive Medicine
- Obstetric Labor, Premature
- Infant, Newborn
- Humans
- Genotype
- Female
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- alpha 1-Antitrypsin Deficiency
- alpha 1-Antitrypsin
- Pregnancy Complications
- Pregnancy
- Obstetrics & Reproductive Medicine
- Obstetric Labor, Premature
- Infant, Newborn
- Humans
- Genotype
- Female