Skip to main content
Journal cover image

Alpha 1-antitrypsin deficiency and pregnancy.

Publication ,  Journal Article
Kuller, JA; Katz, VL; McCoy, MC; Bristow, CL
Published in: Am J Perinatol
September 1995

Alpha1-antitrypsin deficiency is an inherited pulmonary disorder which results from a deficiency of a major plasma protease inhibitor. The onset and severity of symptoms vary widely and depend on the genotype and whether the patient smokes cigarettes. Alpha1-antitrypsin in pregnancy has only been previously reported twice. Our patient had a functional serum alpha1-antitrypsin level which was 15% of normal but was clinically asymptomatic and she did not smoke. Her genotype revealed a non-ZZ pattern. Her obstetric history was complicated by preterm labor in each of her five ongoing pregnancies. Alpha1-antitrypsin deficiency is inherited via two codominant autosomal genes. Although there is great variability in severity of disease, seriously affected patients may have emphysema and hepatic abnormalities. Patients with non-ZZ genotypes or who are heterozygotes may have favorable pregnancy outcomes.

Duke Scholars

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

September 1995

Volume

12

Issue

5

Start / End Page

303 / 305

Location

United States

Related Subject Headings

  • alpha 1-Antitrypsin Deficiency
  • alpha 1-Antitrypsin
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obstetric Labor, Premature
  • Infant, Newborn
  • Humans
  • Genotype
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuller, J. A., Katz, V. L., McCoy, M. C., & Bristow, C. L. (1995). Alpha 1-antitrypsin deficiency and pregnancy. Am J Perinatol, 12(5), 303–305. https://doi.org/10.1055/s-2007-994480
Kuller, J. A., V. L. Katz, M. C. McCoy, and C. L. Bristow. “Alpha 1-antitrypsin deficiency and pregnancy.Am J Perinatol 12, no. 5 (September 1995): 303–5. https://doi.org/10.1055/s-2007-994480.
Kuller JA, Katz VL, McCoy MC, Bristow CL. Alpha 1-antitrypsin deficiency and pregnancy. Am J Perinatol. 1995 Sep;12(5):303–5.
Kuller, J. A., et al. “Alpha 1-antitrypsin deficiency and pregnancy.Am J Perinatol, vol. 12, no. 5, Sept. 1995, pp. 303–05. Pubmed, doi:10.1055/s-2007-994480.
Kuller JA, Katz VL, McCoy MC, Bristow CL. Alpha 1-antitrypsin deficiency and pregnancy. Am J Perinatol. 1995 Sep;12(5):303–305.
Journal cover image

Published In

Am J Perinatol

DOI

ISSN

0735-1631

Publication Date

September 1995

Volume

12

Issue

5

Start / End Page

303 / 305

Location

United States

Related Subject Headings

  • alpha 1-Antitrypsin Deficiency
  • alpha 1-Antitrypsin
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Obstetric Labor, Premature
  • Infant, Newborn
  • Humans
  • Genotype
  • Female