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Early postpartum endometritis. Randomized comparison of ampicillin/sulbactam vs. ampicillin, gentamicin and clindamycin.

Publication ,  Journal Article
Resnik, E; Harger, JH; Kuller, JA
Published in: J Reprod Med
June 1994

Seventy-six parturients with a clinical diagnosis of early postpartum endometritis were randomized to be treated with either standard therapy--ampicillin, gentamicin and clindamycin--or a new regimen, ampicillin/sulbactam. We deliberately chose to administer 1.5 g of ampicillin/sulbactam rather than a 3-g dose every six hours in order to accentuate any differences that might occur between the regimens. Failure rates, days of therapy and cost of treatment were compared. There was no statistically significant difference (P > .9) in the failure or recovery rates: 4 of 42 (9.5%) patients failed standard therapy vs. 6 of 34 (17.6%) patients in the ampicillin/sulbactam group. The times to recovery were 3.6 +/- 1.8 SD and 3.3 +/- 1.3 days, respectively. There was no difference in side effects or drug toxicity between the two groups. The cost of standard therapy was $355.32 for 3.6 days, whereas ampicillin/sulbactam cost $139.49 for 3.3 days. Therapy with ampicillin/sulbactam may be an equally effective and efficient way to treat patients with early postpartum endometritis.

Duke Scholars

Published In

J Reprod Med

ISSN

0024-7758

Publication Date

June 1994

Volume

39

Issue

6

Start / End Page

467 / 472

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Sulbactam
  • Puerperal Infection
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gentamicins
  • Female
  • Endometritis
  • Drug Therapy, Combination
 

Citation

APA
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MLA
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Resnik, E., Harger, J. H., & Kuller, J. A. (1994). Early postpartum endometritis. Randomized comparison of ampicillin/sulbactam vs. ampicillin, gentamicin and clindamycin. J Reprod Med, 39(6), 467–472.
Resnik, E., J. H. Harger, and J. A. Kuller. “Early postpartum endometritis. Randomized comparison of ampicillin/sulbactam vs. ampicillin, gentamicin and clindamycin.J Reprod Med 39, no. 6 (June 1994): 467–72.
Resnik, E., et al. “Early postpartum endometritis. Randomized comparison of ampicillin/sulbactam vs. ampicillin, gentamicin and clindamycin.J Reprod Med, vol. 39, no. 6, June 1994, pp. 467–72.

Published In

J Reprod Med

ISSN

0024-7758

Publication Date

June 1994

Volume

39

Issue

6

Start / End Page

467 / 472

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Treatment Failure
  • Sulbactam
  • Puerperal Infection
  • Obstetrics & Reproductive Medicine
  • Humans
  • Gentamicins
  • Female
  • Endometritis
  • Drug Therapy, Combination