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Toward an animal model for antisocial behavior: parallels between mice and humans.

Publication ,  Journal Article
Sluyter, F; Arseneault, L; Moffitt, TE; Veenema, AH; de Boer, S; Koolhaas, JM
Published in: Behavior genetics
September 2003

The goal of this article is to examine whether mouse lines genetically selected for short and long attack latencies are good animal models for antisocial behavior in humans. To this end, we compared male Short and Long Attack Latency mice (SAL and LAL, respectively) with the extremes of the Dunedin Multidisciplinary Health and Development Study (men who persistently displayed antisocial behavior [Persisters] and men who never manifested antisocial behavior [Abstainers]). Groups were compared on the basis of five distinct domains: aggression/violence, reproduction, cognition, behavioral disorders, and endophenotypes. Our observations point to considerable parallels between, on one side, SAL and Persisters, and, on the other side, between LAL and Abstainers (but to a lesser extent). We believe that SAL and LAL are good mouse models to study the development of antisocial behavior and will yield valuable and testable hypotheses with regard to the neurobiological and genetical architecture of antisocial behavior.

Duke Scholars

Published In

Behavior genetics

DOI

EISSN

1573-3297

ISSN

0001-8244

Publication Date

September 2003

Volume

33

Issue

5

Start / End Page

563 / 574

Related Subject Headings

  • Violence
  • Species Specificity
  • Reproduction
  • Reference Values
  • Reaction Time
  • Phenotype
  • Monoamine Oxidase
  • Models, Genetic
  • Models, Animal
  • Mice
 

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Sluyter, F., Arseneault, L., Moffitt, T. E., Veenema, A. H., de Boer, S., & Koolhaas, J. M. (2003). Toward an animal model for antisocial behavior: parallels between mice and humans. Behavior Genetics, 33(5), 563–574. https://doi.org/10.1023/a:1025730901955
Sluyter, Frans, Louise Arseneault, Terrie E. Moffitt, Alexa H. Veenema, Sietse de Boer, and Jaap M. Koolhaas. “Toward an animal model for antisocial behavior: parallels between mice and humans.Behavior Genetics 33, no. 5 (September 2003): 563–74. https://doi.org/10.1023/a:1025730901955.
Sluyter F, Arseneault L, Moffitt TE, Veenema AH, de Boer S, Koolhaas JM. Toward an animal model for antisocial behavior: parallels between mice and humans. Behavior genetics. 2003 Sep;33(5):563–74.
Sluyter, Frans, et al. “Toward an animal model for antisocial behavior: parallels between mice and humans.Behavior Genetics, vol. 33, no. 5, Sept. 2003, pp. 563–74. Epmc, doi:10.1023/a:1025730901955.
Sluyter F, Arseneault L, Moffitt TE, Veenema AH, de Boer S, Koolhaas JM. Toward an animal model for antisocial behavior: parallels between mice and humans. Behavior genetics. 2003 Sep;33(5):563–574.
Journal cover image

Published In

Behavior genetics

DOI

EISSN

1573-3297

ISSN

0001-8244

Publication Date

September 2003

Volume

33

Issue

5

Start / End Page

563 / 574

Related Subject Headings

  • Violence
  • Species Specificity
  • Reproduction
  • Reference Values
  • Reaction Time
  • Phenotype
  • Monoamine Oxidase
  • Models, Genetic
  • Models, Animal
  • Mice