Gene-environment interactions in psychiatry: joining forces with neuroscience.

Published

Journal Article (Review)

Gene-environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene-environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that a gene-environment interactions exist in nature and affect a significant fraction of disease cases. The complementary discipline of epidemiology, experimental neuroscience, fuels gene-environment hypotheses and investigates underlying neural mechanisms. This article discusses opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene-environment interactions.

Full Text

Duke Authors

Cited Authors

  • Caspi, A; Moffitt, TE

Published Date

  • July 2006

Published In

Volume / Issue

  • 7 / 7

Start / End Page

  • 583 - 590

PubMed ID

  • 16791147

Pubmed Central ID

  • 16791147

Electronic International Standard Serial Number (EISSN)

  • 1471-0048

International Standard Serial Number (ISSN)

  • 1471-003X

Digital Object Identifier (DOI)

  • 10.1038/nrn1925

Language

  • eng