Locally advanced pancreatic cancer.


Journal Article (Review)

Of the 32,180 patients diagnosed with pancreatic carcinoma in the United States this year, approximately 40% will present with locally advanced disease. Radiotherapeutic approaches are often employed because these patients have unresectable tumors by virtue of local invasion into the retroperitoneal vessels in the absence of clinically detectable metastases. These treatments include external-beam irradiation with and without fluorouracil-based chemotherapy, intraoperative irradiation, and, more recently, external-beam irradiation with new systemic targeted agents.

Full Text

Duke Authors

Cited Authors

  • Willett, CG; Czito, BG; Bendell, JC; Ryan, DP

Published Date

  • July 2005

Published In

Volume / Issue

  • 23 / 20

Start / End Page

  • 4538 - 4544

PubMed ID

  • 16002845

Pubmed Central ID

  • 16002845

Electronic International Standard Serial Number (EISSN)

  • 1527-7755

International Standard Serial Number (ISSN)

  • 0732-183X

Digital Object Identifier (DOI)

  • 10.1200/jco.2005.23.911


  • eng