Transcriptional regulation of the human T cell receptor delta gene.


Journal Article (Review)

T cell receptor delta gene expression is regulated by a T cell-specific transcriptional enhancer located within the J delta 3-C delta intron. An essential element of the enhancer was localized to a small 30 bp segment denoted delta E3. Two specific factors, CBF/PEBP2 and c-Myb, bind to adjacent sites within delta E3 and cooperate functionally to mediate transcriptional activation. These factors are likely to play essential roles in the developmental activation of the TCR delta gene in vivo.

Full Text

Duke Authors

Cited Authors

  • Redondo, JM; Hernandez-Munain, C; Krangel, MS

Published Date

  • July 1995

Published In

Volume / Issue

  • 193 / 2-4

Start / End Page

  • 288 - 292

PubMed ID

  • 8530157

Pubmed Central ID

  • 8530157

International Standard Serial Number (ISSN)

  • 0171-2985

Digital Object Identifier (DOI)

  • 10.1016/s0171-2985(11)80557-7


  • eng

Conference Location

  • Netherlands