A role for histone acetylation in the developmental regulation of VDJ recombination.
Publication
, Journal Article
McMurry, MT; Krangel, MS
Published in: Science
January 21, 2000
VDJ recombination is developmentally regulated in vivo by enhancer-dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic VDJ recombination reporter and the endogenous T cell receptor alpha/delta locus. Enhancer activity was shown to impart long-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to VDJ recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibility for VDJ recombination.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
January 21, 2000
Volume
287
Issue
5452
Start / End Page
495 / 498
Location
United States
Related Subject Headings
- VDJ Recombinases
- Transgenes
- T-Lymphocytes
- Recombination, Genetic
- Protein Sorting Signals
- Nuclear Proteins
- Mice, Transgenic
- Mice
- Humans
- Homeodomain Proteins
Citation
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Chicago
ICMJE
MLA
NLM
McMurry, M. T., & Krangel, M. S. (2000). A role for histone acetylation in the developmental regulation of VDJ recombination. Science, 287(5452), 495–498. https://doi.org/10.1126/science.287.5452.495
McMurry, M. T., and M. S. Krangel. “A role for histone acetylation in the developmental regulation of VDJ recombination.” Science 287, no. 5452 (January 21, 2000): 495–98. https://doi.org/10.1126/science.287.5452.495.
McMurry MT, Krangel MS. A role for histone acetylation in the developmental regulation of VDJ recombination. Science. 2000 Jan 21;287(5452):495–8.
McMurry, M. T., and M. S. Krangel. “A role for histone acetylation in the developmental regulation of VDJ recombination.” Science, vol. 287, no. 5452, Jan. 2000, pp. 495–98. Pubmed, doi:10.1126/science.287.5452.495.
McMurry MT, Krangel MS. A role for histone acetylation in the developmental regulation of VDJ recombination. Science. 2000 Jan 21;287(5452):495–498.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
January 21, 2000
Volume
287
Issue
5452
Start / End Page
495 / 498
Location
United States
Related Subject Headings
- VDJ Recombinases
- Transgenes
- T-Lymphocytes
- Recombination, Genetic
- Protein Sorting Signals
- Nuclear Proteins
- Mice, Transgenic
- Mice
- Humans
- Homeodomain Proteins