A role for histone acetylation in the developmental regulation of VDJ recombination.

Journal Article (Journal Article)

VDJ recombination is developmentally regulated in vivo by enhancer-dependent changes in the accessibility of chromosomal recombination signal sequences to the recombinase, but the molecular nature of these changes is unknown. Here histone H3 acetylation was measured along versions of a transgenic VDJ recombination reporter and the endogenous T cell receptor alpha/delta locus. Enhancer activity was shown to impart long-range, developmentally regulated changes in H3 acetylation, and H3 acetylation status was tightly linked to VDJ recombination. H3 hyperacetylation is proposed as a molecular mechanism coupling enhancer activity to accessibility for VDJ recombination.

Full Text

Duke Authors

Cited Authors

  • McMurry, MT; Krangel, MS

Published Date

  • January 21, 2000

Published In

Volume / Issue

  • 287 / 5452

Start / End Page

  • 495 - 498

PubMed ID

  • 10642553

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.287.5452.495


  • eng

Conference Location

  • United States