Developmental regulation of V(D)J recombination at the TCR alpha/delta locus.

Published

Journal Article (Review)

The T-cell receptor (TCR) alpha/delta locus includes a large number of V, D, J and C gene segments that are used to produce functional TCR delta and TCR alpha chains expressed by distinct subsets of T lymphocytes. V(D)J recombination events within the locus are regulated as a function of developmental stage and cell lineage during T-lymphocyte differentiation in the thymus. The process of V(D)J recombination is regulated by cis-acting elements that modulate the accessibility of chromosomal substrates to the recombinase. Here we evaluate how the assembly of transcription factor complexes onto enhancers, promoters and other regulatory elements within the TCR alpha/delta locus imparts developmental control to VDJ delta and VJ alpha rearrangement events. Furthermore, we develop the notion that within a complex locus such as the TCR alpha/delta locus, highly localized and region-specific control is likely to require an interplay between positive regulatory elements and blocking or boundary elements that restrict the influence of the positive elements to defined regions of the locus.

Full Text

Duke Authors

Cited Authors

  • Krangel, MS; Hernandez-Munain, C; Lauzurica, P; McMurry, M; Roberts, JL; Zhong, XP

Published Date

  • October 1998

Published In

Volume / Issue

  • 165 /

Start / End Page

  • 131 - 147

PubMed ID

  • 9850858

Pubmed Central ID

  • 9850858

International Standard Serial Number (ISSN)

  • 0105-2896

Digital Object Identifier (DOI)

  • 10.1111/j.1600-065x.1998.tb01236.x

Language

  • eng

Conference Location

  • England