Gene segment selection in V(D)J recombination: accessibility and beyond.
V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.
Duke Scholars
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Related Subject Headings
- Recombination, Genetic
- Receptors, Antigen, T-Cell
- Promoter Regions, Genetic
- Immunology
- Immunoglobulin Variable Region
- Immunoglobulin Joining Region
- Humans
- Histones
- Genes, Immunoglobulin
- Gene Rearrangement
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Recombination, Genetic
- Receptors, Antigen, T-Cell
- Promoter Regions, Genetic
- Immunology
- Immunoglobulin Variable Region
- Immunoglobulin Joining Region
- Humans
- Histones
- Genes, Immunoglobulin
- Gene Rearrangement