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Gene segment selection in V(D)J recombination: accessibility and beyond.

Publication ,  Journal Article
Krangel, MS
Published in: Nat Immunol
July 2003

V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.

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Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

July 2003

Volume

4

Issue

7

Start / End Page

624 / 630

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Immunology
  • Immunoglobulin Variable Region
  • Immunoglobulin Joining Region
  • Humans
  • Histones
  • Genes, Immunoglobulin
  • Gene Rearrangement
 

Citation

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Krangel, M. S. (2003). Gene segment selection in V(D)J recombination: accessibility and beyond. Nat Immunol, 4(7), 624–630. https://doi.org/10.1038/ni0703-624
Krangel, Michael S. “Gene segment selection in V(D)J recombination: accessibility and beyond.Nat Immunol 4, no. 7 (July 2003): 624–30. https://doi.org/10.1038/ni0703-624.
Krangel MS. Gene segment selection in V(D)J recombination: accessibility and beyond. Nat Immunol. 2003 Jul;4(7):624–30.
Krangel, Michael S. “Gene segment selection in V(D)J recombination: accessibility and beyond.Nat Immunol, vol. 4, no. 7, July 2003, pp. 624–30. Pubmed, doi:10.1038/ni0703-624.
Krangel MS. Gene segment selection in V(D)J recombination: accessibility and beyond. Nat Immunol. 2003 Jul;4(7):624–630.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

July 2003

Volume

4

Issue

7

Start / End Page

624 / 630

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Immunology
  • Immunoglobulin Variable Region
  • Immunoglobulin Joining Region
  • Humans
  • Histones
  • Genes, Immunoglobulin
  • Gene Rearrangement