Gene segment selection in V(D)J recombination: accessibility and beyond.

Journal Article (Journal Article;Review)

V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.

Full Text

Duke Authors

Cited Authors

  • Krangel, MS

Published Date

  • July 2003

Published In

Volume / Issue

  • 4 / 7

Start / End Page

  • 624 - 630

PubMed ID

  • 12830137

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/ni0703-624


  • eng

Conference Location

  • United States