Gene segment selection in V(D)J recombination: accessibility and beyond.
Journal Article (Journal Article;Review)
V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency and specificity in ways that had not been previously appreciated. Recent developments have increased our understanding of how the chromatin barrier to V(D)J recombination is regulated, and how chromatin control and the properties of the underlying recombination signal sequences may cooperate to create diverse, lineage-restricted and allelically excluded repertoires of antigen receptors.
Full Text
Duke Authors
Cited Authors
- Krangel, MS
Published Date
- July 2003
Published In
Volume / Issue
- 4 / 7
Start / End Page
- 624 - 630
PubMed ID
- 12830137
International Standard Serial Number (ISSN)
- 1529-2908
Digital Object Identifier (DOI)
- 10.1038/ni0703-624
Language
- eng
Conference Location
- United States