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Delineation of immunologically and biochemically distinct HLA-A2 antigens.

Publication ,  Journal Article
Biddison, WE; Kostyu, DD; Strominger, JL; Krangel, MS
Published in: J Immunol
August 1982

Cytotoxic T cell (CTL) recognition of influenza virus in conjunction with HLA-A2 was examined in a population study. Virus-infected target cells from three unrelated A2-positive donors were not lysed by virus-immune CTL from any donor matched only for A2. The A2 antigens of these three donors were indistinguishable from the A2 antigens of other A2-positive donors as assessed by extensive serologic analyses; however, isoelectric focusing (IEF) of A2 molecules from these three donors demonstrated that their A2 heavy polypeptide chains are structurally distinct from those of "normal" A2-positive donors. To date 11% of all A2-positive donors tested exhibited a "variant" A2-associated CTL restriction antigen, and IEF of A2 heavy chains from all "variant" A2-positive cells revealed structural differences in each of these polypeptides. These results suggest there may be considerably greater polymorphism of HLA-A gene products than has been revealed by current serologic techniques.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

August 1982

Volume

129

Issue

2

Start / End Page

730 / 734

Location

United States

Related Subject Headings

  • Isoelectric Focusing
  • Influenza A virus
  • Immunology
  • Immunoglobulin Heavy Chains
  • Humans
  • HLA-A2 Antigen
  • HLA Antigens
  • Epitopes
  • Chemistry
  • Chemical Phenomena
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Biddison, W. E., Kostyu, D. D., Strominger, J. L., & Krangel, M. S. (1982). Delineation of immunologically and biochemically distinct HLA-A2 antigens. J Immunol, 129(2), 730–734.
Biddison, W. E., D. D. Kostyu, J. L. Strominger, and M. S. Krangel. “Delineation of immunologically and biochemically distinct HLA-A2 antigens.J Immunol 129, no. 2 (August 1982): 730–34.
Biddison WE, Kostyu DD, Strominger JL, Krangel MS. Delineation of immunologically and biochemically distinct HLA-A2 antigens. J Immunol. 1982 Aug;129(2):730–4.
Biddison, W. E., et al. “Delineation of immunologically and biochemically distinct HLA-A2 antigens.J Immunol, vol. 129, no. 2, Aug. 1982, pp. 730–34.
Biddison WE, Kostyu DD, Strominger JL, Krangel MS. Delineation of immunologically and biochemically distinct HLA-A2 antigens. J Immunol. 1982 Aug;129(2):730–734.

Published In

J Immunol

ISSN

0022-1767

Publication Date

August 1982

Volume

129

Issue

2

Start / End Page

730 / 734

Location

United States

Related Subject Headings

  • Isoelectric Focusing
  • Influenza A virus
  • Immunology
  • Immunoglobulin Heavy Chains
  • Humans
  • HLA-A2 Antigen
  • HLA Antigens
  • Epitopes
  • Chemistry
  • Chemical Phenomena