Delineation of immunologically and biochemically distinct HLA-A2 antigens.

Published

Journal Article

Cytotoxic T cell (CTL) recognition of influenza virus in conjunction with HLA-A2 was examined in a population study. Virus-infected target cells from three unrelated A2-positive donors were not lysed by virus-immune CTL from any donor matched only for A2. The A2 antigens of these three donors were indistinguishable from the A2 antigens of other A2-positive donors as assessed by extensive serologic analyses; however, isoelectric focusing (IEF) of A2 molecules from these three donors demonstrated that their A2 heavy polypeptide chains are structurally distinct from those of "normal" A2-positive donors. To date 11% of all A2-positive donors tested exhibited a "variant" A2-associated CTL restriction antigen, and IEF of A2 heavy chains from all "variant" A2-positive cells revealed structural differences in each of these polypeptides. These results suggest there may be considerably greater polymorphism of HLA-A gene products than has been revealed by current serologic techniques.

Full Text

Duke Authors

Cited Authors

  • Biddison, WE; Kostyu, DD; Strominger, JL; Krangel, MS

Published Date

  • August 1, 1982

Published In

Volume / Issue

  • 129 / 2

Start / End Page

  • 730 - 734

PubMed ID

  • 6177780

Pubmed Central ID

  • 6177780

International Standard Serial Number (ISSN)

  • 0022-1767

Language

  • eng

Conference Location

  • United States