A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.

Journal Article (Journal Article)

The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.

Full Text

Duke Authors

Cited Authors

  • Redondo, JM; Hata, S; Brocklehurst, C; Krangel, MS

Published Date

  • March 9, 1990

Published In

Volume / Issue

  • 247 / 4947

Start / End Page

  • 1225 - 1229

PubMed ID

  • 2156339

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2156339


  • eng

Conference Location

  • United States