A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.
Journal Article (Journal Article)
The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.
- Redondo, JM; Hata, S; Brocklehurst, C; Krangel, MS
- March 9, 1990
Volume / Issue
- 247 / 4947
Start / End Page
- 1225 - 1229
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States