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A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.

Publication ,  Journal Article
Redondo, JM; Hata, S; Brocklehurst, C; Krangel, MS
Published in: Science
March 9, 1990

The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 9, 1990

Volume

247

Issue

4947

Start / End Page

1225 / 1229

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Plasmids
  • Nuclear Proteins
  • Mutation
  • Molecular Sequence Data
  • Humans
 

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Redondo, J. M., Hata, S., Brocklehurst, C., & Krangel, M. S. (1990). A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. Science, 247(4947), 1225–1229. https://doi.org/10.1126/science.2156339
Redondo, J. M., S. Hata, C. Brocklehurst, and M. S. Krangel. “A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.Science 247, no. 4947 (March 9, 1990): 1225–29. https://doi.org/10.1126/science.2156339.
Redondo JM, Hata S, Brocklehurst C, Krangel MS. A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. Science. 1990 Mar 9;247(4947):1225–9.
Redondo, J. M., et al. “A T cell-specific transcriptional enhancer within the human T cell receptor delta locus.Science, vol. 247, no. 4947, Mar. 1990, pp. 1225–29. Pubmed, doi:10.1126/science.2156339.
Redondo JM, Hata S, Brocklehurst C, Krangel MS. A T cell-specific transcriptional enhancer within the human T cell receptor delta locus. Science. 1990 Mar 9;247(4947):1225–1229.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 9, 1990

Volume

247

Issue

4947

Start / End Page

1225 / 1229

Location

United States

Related Subject Headings

  • Transfection
  • Transcription, Genetic
  • Repetitive Sequences, Nucleic Acid
  • Receptors, Antigen, T-Cell
  • Promoter Regions, Genetic
  • Plasmids
  • Nuclear Proteins
  • Mutation
  • Molecular Sequence Data
  • Humans