Identification of putative human T cell receptor delta complementary DNA clones.

Published

Journal Article

A novel T cell receptor (TCR) subunit termed TCR delta, associated with TCR gamma and CD3 polypeptides, was recently found on a subpopulation of human T lymphocytes. T cell-specific complementary DNA clones present in a human TCR gamma delta T cell complementary DNA library were obtained and characterized in order to identify candidate clones encoding TCR delta. One cross-hybridizing group of clones detected transcripts that are expressed in lymphocytes bearing TCR gamma delta but not in other T lymphocytes and are encoded by genes that are rearranged in TCR gamma delta lymphocytes but deleted in other T lymphocytes. Their sequences indicate homology to the variable, joining, and constant elements of other TCR and immunoglobulin genes. These characteristics, as well as the immunochemical data presented in a companion paper, are strong evidence that the complementary DNA clones encode TCR delta.

Full Text

Duke Authors

Cited Authors

  • Hata, S; Brenner, MB; Krangel, MS

Published Date

  • October 30, 1987

Published In

Volume / Issue

  • 238 / 4827

Start / End Page

  • 678 - 682

PubMed ID

  • 3499667

Pubmed Central ID

  • 3499667

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3499667

Language

  • eng

Conference Location

  • United States