Identification of putative human T cell receptor delta complementary DNA clones.
Journal Article (Journal Article)
A novel T cell receptor (TCR) subunit termed TCR delta, associated with TCR gamma and CD3 polypeptides, was recently found on a subpopulation of human T lymphocytes. T cell-specific complementary DNA clones present in a human TCR gamma delta T cell complementary DNA library were obtained and characterized in order to identify candidate clones encoding TCR delta. One cross-hybridizing group of clones detected transcripts that are expressed in lymphocytes bearing TCR gamma delta but not in other T lymphocytes and are encoded by genes that are rearranged in TCR gamma delta lymphocytes but deleted in other T lymphocytes. Their sequences indicate homology to the variable, joining, and constant elements of other TCR and immunoglobulin genes. These characteristics, as well as the immunochemical data presented in a companion paper, are strong evidence that the complementary DNA clones encode TCR delta.
Full Text
Duke Authors
Cited Authors
- Hata, S; Brenner, MB; Krangel, MS
Published Date
- October 30, 1987
Published In
Volume / Issue
- 238 / 4827
Start / End Page
- 678 - 682
PubMed ID
- 3499667
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.3499667
Language
- eng
Conference Location
- United States