Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.

Published

Journal Article

The human T cell receptor (TCR) gamma polypeptide occurs in structurally distinct forms on certain peripheral blood T lymphocytes. Complementary DNA clones representing the transcripts of functionally rearranged TCR gamma genes in these cells have been analyzed. The expression of a disulfide-linked and a nondisulfide-linked form of TCR gamma correlates with the use of the C gamma 1 and C gamma 2 constant-region gene segments, respectively. Variability in TCR gamma polypeptide size and disulfide linkage is determined by the number of copies and the sequence of a repeated segment of the constant region. Thus C gamma 1 and C gamma 2 are used to generate structurally distinct, yet functional, T3-associated receptor complexes on peripheral blood lymphocytes. Tryptic peptide mapping suggests that the T3-associated TCR gamma and delta peptides in the nondisulfide-linked form are distinct.

Full Text

Duke Authors

Cited Authors

  • Krangel, MS; Band, H; Hata, S; McLean, J; Brenner, MB

Published Date

  • July 1, 1987

Published In

Volume / Issue

  • 237 / 4810

Start / End Page

  • 64 - 67

PubMed ID

  • 2955517

Pubmed Central ID

  • 2955517

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2955517

Language

  • eng