Structurally divergent human T cell receptor gamma proteins encoded by distinct C gamma genes.
Journal Article (Journal Article)
The human T cell receptor (TCR) gamma polypeptide occurs in structurally distinct forms on certain peripheral blood T lymphocytes. Complementary DNA clones representing the transcripts of functionally rearranged TCR gamma genes in these cells have been analyzed. The expression of a disulfide-linked and a nondisulfide-linked form of TCR gamma correlates with the use of the C gamma 1 and C gamma 2 constant-region gene segments, respectively. Variability in TCR gamma polypeptide size and disulfide linkage is determined by the number of copies and the sequence of a repeated segment of the constant region. Thus C gamma 1 and C gamma 2 are used to generate structurally distinct, yet functional, T3-associated receptor complexes on peripheral blood lymphocytes. Tryptic peptide mapping suggests that the T3-associated TCR gamma and delta peptides in the nondisulfide-linked form are distinct.
Full Text
Duke Authors
Cited Authors
- Krangel, MS; Band, H; Hata, S; McLean, J; Brenner, MB
Published Date
- July 3, 1987
Published In
Volume / Issue
- 237 / 4810
Start / End Page
- 64 - 67
PubMed ID
- 2955517
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.2955517
Language
- eng
Conference Location
- United States