Life after the screen: making sense of many P-values.

Journal Article (Journal Article)

A multiple analytic approach may be useful for analyzing complex traits since different methods extract both similar and distinct, but complementary pieces of information from genome screen data on extended pedigrees. We examined the usefulness of combining p-values both across methods and across adjacent markers, taking into account the observed correlation structure among these p-values. To this end, we employed the recently proposed truncated product method [Zaykin et al., Genet Epidemiol, in press]. It appears that this approach is helpful for visualizing priority regions for follow-up analysis and reducing the number of false-positive linkage signals.

Full Text

Duke Authors

Cited Authors

  • Schmidt, S; Shao, Y; Hauser, ER; Slifer, SH; Martin, ER; Scott, WK; Speer, MC; Pericak-Vance, MA

Published Date

  • 2001

Published In

Volume / Issue

  • 21 Suppl 1 /

Start / End Page

  • S546 - S551

PubMed ID

  • 11793734

International Standard Serial Number (ISSN)

  • 0741-0395

Digital Object Identifier (DOI)

  • 10.1002/gepi.2001.21.s1.s546


  • eng

Conference Location

  • United States