Skip to main content

Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.

Publication ,  Journal Article
Valle, T; Tuomilehto, J; Bergman, RN; Ghosh, S; Hauser, ER; Eriksson, J; Nylund, SJ; Kohtamäki, K; Toivanen, L; Vidgren, G; Tuomilehto-Wolf, E ...
Published in: Diabetes Care
June 1998

OBJECTIVE: To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM. RESEARCH DESIGN AND METHODS: We describe the methodology and sample of the Finland-United States Investigation of NIDDM Genetics (FUSION) study. The whole genome search approach is being applied in studies of several different ethnic groups to locate susceptibility genes for NIDDM. Detailed description of the study materials and designs of such studies are important, particularly when comparing the findings in these studies and when combining different data sets. RESULTS: Using a careful selection strategy, we have ascertained 495 families with confirmed NIDDM in at least two siblings and no history of IDDM among the first-degree relatives. These families were chosen from more than 22,000 NIDDM patients, representative of patients with NIDDM in the Finnish population. In a subset of families, a spouse and offspring were sampled, and they participated in a frequently sampled intravenous glucose tolerance test (FSIGT) analyzed with the Minimal Model. An FSIGT was completed successfully for at least two nondiabetic offspring in 156 families with a confirmed nondiabetic spouse and no history of IDDM in first-degree relatives. CONCLUSIONS: Our work demonstrates the feasibility of collecting a large number of affected sib-pair families with NIDDM to provide data that will enable a whole genome search approach, including linkage analysis.

Duke Scholars

Published In

Diabetes Care

DOI

ISSN

0149-5992

Publication Date

June 1998

Volume

21

Issue

6

Start / End Page

949 / 958

Location

United States

Related Subject Headings

  • United States
  • Sex Characteristics
  • Quantitative Trait, Heritable
  • Phenotype
  • Nuclear Family
  • Middle Aged
  • Male
  • International Cooperation
  • Insulin
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Valle, T., Tuomilehto, J., Bergman, R. N., Ghosh, S., Hauser, E. R., Eriksson, J., … Boehnke, M. (1998). Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care, 21(6), 949–958. https://doi.org/10.2337/diacare.21.6.949
Valle, T., J. Tuomilehto, R. N. Bergman, S. Ghosh, E. R. Hauser, J. Eriksson, S. J. Nylund, et al. “Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.Diabetes Care 21, no. 6 (June 1998): 949–58. https://doi.org/10.2337/diacare.21.6.949.
Valle T, Tuomilehto J, Bergman RN, Ghosh S, Hauser ER, Eriksson J, et al. Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care. 1998 Jun;21(6):949–58.
Valle, T., et al. “Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.Diabetes Care, vol. 21, no. 6, June 1998, pp. 949–58. Pubmed, doi:10.2337/diacare.21.6.949.
Valle T, Tuomilehto J, Bergman RN, Ghosh S, Hauser ER, Eriksson J, Nylund SJ, Kohtamäki K, Toivanen L, Vidgren G, Tuomilehto-Wolf E, Ehnholm C, Blaschak J, Langefeld CD, Watanabe RM, Magnuson V, Ally DS, Hagopian WA, Ross E, Buchanan TA, Collins F, Boehnke M. Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. Diabetes Care. 1998 Jun;21(6):949–958.

Published In

Diabetes Care

DOI

ISSN

0149-5992

Publication Date

June 1998

Volume

21

Issue

6

Start / End Page

949 / 958

Location

United States

Related Subject Headings

  • United States
  • Sex Characteristics
  • Quantitative Trait, Heritable
  • Phenotype
  • Nuclear Family
  • Middle Aged
  • Male
  • International Cooperation
  • Insulin
  • Humans