Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs.

Journal Article (Journal Article)

Multipoint linkage analysis in complex diseases requires the use of fast algorithms that can handle many markers and a large number of moderately sized pedigrees with unknown mode of inheritance. This need has led to the development of several competitive software programs. We recently completed a genomic screen of neural tube defects using GENEHUNTER-PLUS and the more recent ALLEGRO. The ALLEGRO software was found to offer expanded power for linkage studies, particularly for childhood onset diseases like neural tube defects, though the results must be treated with caution.

Full Text

Duke Authors

Cited Authors

  • Rampersaud, E; Scott, WK; Hauser, ER; Speer, MC

Published Date

  • December 2005

Published In

Volume / Issue

  • 42 / 12

Start / End Page

  • e68 -

PubMed ID

  • 16326825

Pubmed Central ID

  • PMC1735966

Electronic International Standard Serial Number (EISSN)

  • 1468-6244

Digital Object Identifier (DOI)

  • 10.1136/jmg.2005.032029


  • eng

Conference Location

  • England