On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.

Published

Journal Article

The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.

Full Text

Duke Authors

Cited Authors

  • Cohn, JA; Alvares, AP; Kappas, A

Published Date

  • June 1, 1977

Published In

Volume / Issue

  • 145 / 6

Start / End Page

  • 1607 - 1611

PubMed ID

  • 194012

Pubmed Central ID

  • 194012

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.145.6.1607

Language

  • eng

Conference Location

  • United States