On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.
Publication
, Journal Article
Cohn, JA; Alvares, AP; Kappas, A
Published in: The Journal of experimental medicine
June 1977
The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.
Duke Scholars
Published In
The Journal of experimental medicine
DOI
EISSN
1540-9538
ISSN
0022-1007
Publication Date
June 1977
Volume
145
Issue
6
Start / End Page
1607 / 1611
Related Subject Headings
- Rats
- NAD
- Microsomes
- Methylmercury Compounds
- Methylcholanthrene
- Male
- Immunology
- Dithionite
- Cytochromes
- Cytochrome P-450 Enzyme System
Citation
APA
Chicago
ICMJE
MLA
NLM
Cohn, J. A., Alvares, A. P., & Kappas, A. (1977). On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of Experimental Medicine, 145(6), 1607–1611. https://doi.org/10.1084/jem.145.6.1607
Cohn, J. A., A. P. Alvares, and A. Kappas. “On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.” The Journal of Experimental Medicine 145, no. 6 (June 1977): 1607–11. https://doi.org/10.1084/jem.145.6.1607.
Cohn JA, Alvares AP, Kappas A. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of experimental medicine. 1977 Jun;145(6):1607–11.
Cohn, J. A., et al. “On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.” The Journal of Experimental Medicine, vol. 145, no. 6, June 1977, pp. 1607–11. Epmc, doi:10.1084/jem.145.6.1607.
Cohn JA, Alvares AP, Kappas A. On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain. The Journal of experimental medicine. 1977 Jun;145(6):1607–1611.
Published In
The Journal of experimental medicine
DOI
EISSN
1540-9538
ISSN
0022-1007
Publication Date
June 1977
Volume
145
Issue
6
Start / End Page
1607 / 1611
Related Subject Headings
- Rats
- NAD
- Microsomes
- Methylmercury Compounds
- Methylcholanthrene
- Male
- Immunology
- Dithionite
- Cytochromes
- Cytochrome P-450 Enzyme System