On the occurrence of cytochrome P-450 and aryl hydrocarbon hydroxylase activity in rat brain.
Journal Article (Journal Article)
The difference spectra of the carbon monoxide-complex of dithionite-reduced rat brain microsomes, compared with both reduced microsomes, alone, and the carbon monoxide-complex of oxidized microsomes, indicate the presence of small amounts of cytochrome P-450 in brain. As in liver, cytochrome P-450 in brain is degraded in vitro to its inactive form, cytochrome P-420 by methylmercury chloride. Aryl hydrocarbon hydroxylase activity is also present in rat brain microsomes and, at lower specific activity, in brain homogenates. This carcinogen metabolizing activity is increased four-fold in rats pretreated with 3-methylcholanthrene.
Full Text
Duke Authors
Cited Authors
- Cohn, JA; Alvares, AP; Kappas, A
Published Date
- June 1, 1977
Published In
Volume / Issue
- 145 / 6
Start / End Page
- 1607 - 1611
PubMed ID
- 194012
Pubmed Central ID
- PMC2180688
International Standard Serial Number (ISSN)
- 0022-1007
Digital Object Identifier (DOI)
- 10.1084/jem.145.6.1607
Language
- eng
Conference Location
- United States