Are mutations in the cystic fibrosis gene important in chronic pancreatitis?

Journal Article (Journal Article;Review)

The leading causes of chronic pancreatitis are alcohol and idiopathic pancreatitis. The importance of genetic factors in chronic pancreatitis has been uncertain. Recently, however, it was learned that many patients with idiopathic chronic pancreatitis have mutations of the cystic fibrosis gene. This article reviews the evidence that links mutations of this gene to unexplained pancreatitis, and discusses the implications of this for the evaluation, pathogenesis, classification, and possible prevention of pancreatitis.

Full Text

Duke Authors

Cited Authors

  • Cohn, JA; Jowell, PS

Published Date

  • August 1999

Published In

Volume / Issue

  • 79 / 4

Start / End Page

  • 723 - viii

PubMed ID

  • 10470322

International Standard Serial Number (ISSN)

  • 0039-6109

Digital Object Identifier (DOI)

  • 10.1016/s0039-6109(05)70038-4


  • eng

Conference Location

  • United States