Cystic fibrosis mutations and genetic predisposition to idiopathic chronic pancreatitis.

Published

Journal Article (Review)

Idiopathic chronic pancreatitis is a leading cause of chronic pancreatitis. Work from this and other groups has shown that idiopathic chronic pancreatitis is associated with mutations of the cystic fibrosis gene (CFTR). Many idiopathic pancreatitis patients have compound heterozygote genotypes in which both copies of the CFTR gene are abnormal. In these patients, the pancreatic disease can be viewed as a mild variant of cystic fibrosis, in which there is sufficient residual CFTR function to prevent lung disease. This article summarizes the evidence associating these abnormal CFTR genotypes with idiopathic chronic pancreatitis and reviews the implications of this association for the pathogenesis, classification, and prevention of pancreatitis.

Full Text

Duke Authors

Cited Authors

  • Cohn, JA; Bornstein, JD; Jowell, PS

Published Date

  • May 2000

Published In

Volume / Issue

  • 84 / 3

Start / End Page

  • 621 - ix

PubMed ID

  • 10872419

Pubmed Central ID

  • 10872419

International Standard Serial Number (ISSN)

  • 0025-7125

Digital Object Identifier (DOI)

  • 10.1016/s0025-7125(05)70245-5

Language

  • eng

Conference Location

  • United States