Abnormal exhaled ethane concentrations in scleroderma.

Published

Journal Article

Scleroderma (systemic sclerosis) is a chronic multisystem autoimmune disease in which oxidative stress is suspected to play a role in the pathophysiology. Therefore, it was postulated that patients with scleroderma would have abnormally high breath ethane concentrations, which is a volatile product of free-radical-mediated lipid peroxidation, compared with a group of controls. There was a significant difference (p<0.05) between the mean exhaled ethane concentration of 5.27 pmol ml(-1) CO(2) (SEM=0.76) in the scleroderma patients (n=36) versus the mean exhaled concentration of 2.72 pmol ml(-1) CO(2) (SEM=0.71) in a group of healthy controls (n=21). Within the scleroderma group, those subjects taking a calcium channel blocker had lower ethane concentrations compared with patients who were not taking these drugs (p=0.05). There was a significant inverse association between lung diffusion capacity for carbon monoxide (per cent of predicted) and ethane concentration (b=-2.8, p=0.026, CI=-5.2 to -0.35). These data support the presence of increased oxidative stress among patients with scleroderma that is detected by measuring breath ethane concentrations.

Full Text

Duke Authors

Cited Authors

  • Cope, KA; Solga, SF; Hummers, LK; Wigley, FM; Diehl, AM; Risby, TH

Published Date

  • January 2006

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 70 - 84

PubMed ID

  • 16484138

Pubmed Central ID

  • 16484138

International Standard Serial Number (ISSN)

  • 1354-750X

Digital Object Identifier (DOI)

  • 10.1080/13547500500515046

Language

  • eng

Conference Location

  • England