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Abnormal exhaled ethane concentrations in scleroderma.

Publication ,  Journal Article
Cope, KA; Solga, SF; Hummers, LK; Wigley, FM; Diehl, AM; Risby, TH
Published in: Biomarkers
2006

Scleroderma (systemic sclerosis) is a chronic multisystem autoimmune disease in which oxidative stress is suspected to play a role in the pathophysiology. Therefore, it was postulated that patients with scleroderma would have abnormally high breath ethane concentrations, which is a volatile product of free-radical-mediated lipid peroxidation, compared with a group of controls. There was a significant difference (p<0.05) between the mean exhaled ethane concentration of 5.27 pmol ml(-1) CO(2) (SEM=0.76) in the scleroderma patients (n=36) versus the mean exhaled concentration of 2.72 pmol ml(-1) CO(2) (SEM=0.71) in a group of healthy controls (n=21). Within the scleroderma group, those subjects taking a calcium channel blocker had lower ethane concentrations compared with patients who were not taking these drugs (p=0.05). There was a significant inverse association between lung diffusion capacity for carbon monoxide (per cent of predicted) and ethane concentration (b=-2.8, p=0.026, CI=-5.2 to -0.35). These data support the presence of increased oxidative stress among patients with scleroderma that is detected by measuring breath ethane concentrations.

Duke Scholars

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

2006

Volume

11

Issue

1

Start / End Page

70 / 84

Location

England

Related Subject Headings

  • Toxicology
  • Scleroderma, Systemic
  • Middle Aged
  • Lung Volume Measurements
  • Lipid Peroxidation
  • Humans
  • Ethanol
  • Ethane
  • Breath Tests
  • 4103 Environmental biotechnology
 

Citation

APA
Chicago
ICMJE
MLA
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Cope, K. A., Solga, S. F., Hummers, L. K., Wigley, F. M., Diehl, A. M., & Risby, T. H. (2006). Abnormal exhaled ethane concentrations in scleroderma. Biomarkers, 11(1), 70–84. https://doi.org/10.1080/13547500500515046
Cope, K. A., S. F. Solga, L. K. Hummers, F. M. Wigley, A. M. Diehl, and T. H. Risby. “Abnormal exhaled ethane concentrations in scleroderma.Biomarkers 11, no. 1 (2006): 70–84. https://doi.org/10.1080/13547500500515046.
Cope KA, Solga SF, Hummers LK, Wigley FM, Diehl AM, Risby TH. Abnormal exhaled ethane concentrations in scleroderma. Biomarkers. 2006;11(1):70–84.
Cope, K. A., et al. “Abnormal exhaled ethane concentrations in scleroderma.Biomarkers, vol. 11, no. 1, 2006, pp. 70–84. Pubmed, doi:10.1080/13547500500515046.
Cope KA, Solga SF, Hummers LK, Wigley FM, Diehl AM, Risby TH. Abnormal exhaled ethane concentrations in scleroderma. Biomarkers. 2006;11(1):70–84.
Journal cover image

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

2006

Volume

11

Issue

1

Start / End Page

70 / 84

Location

England

Related Subject Headings

  • Toxicology
  • Scleroderma, Systemic
  • Middle Aged
  • Lung Volume Measurements
  • Lipid Peroxidation
  • Humans
  • Ethanol
  • Ethane
  • Breath Tests
  • 4103 Environmental biotechnology