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Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations.

Publication ,  Journal Article
Solga, SF; Alkhuraishe, A; Cope, K; Tabesh, A; Clark, JM; Torbenson, M; Schwartz, P; Magnuson, T; Diehl, AM; Risby, TH
Published in: Biomarkers
2006

Breath biomarkers have the potential to offer information that is similar to conventional clinical tests or they are entirely unique. Preliminary data support the use of breath biomarkers in the study of liver disease, in particular non-alcoholic fatty liver disease (NAFLD). It was evaluated whether breath ethanol, ethane, sulfur compounds and acetone would be associated with hepatic histopathology amongst morbidly obese patients presenting for bariatric surgery. Breath samples were collected during a preoperative visit and compared with liver biopsies obtained during the surgery. A Student's two-tailed t-test was used to compare differences between the two groups. Linear regression was used to analyse associations between the concentrations of breath molecules and independent predictor variables. It was found that breath ethanol, ethane and acetone can be useful biomarkers in patients with NAFLD. In particular, breath ethanol can be associated with hepatic steatosis, and breath acetone can be associated with non-alcoholic steatohepatitis.

Duke Scholars

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

2006

Volume

11

Issue

2

Start / End Page

174 / 183

Location

England

Related Subject Headings

  • Toxicology
  • Sulfur
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatty Liver
  • Ethanol
  • Carbon Dioxide
  • Breath Tests
 

Citation

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Solga, S. F., Alkhuraishe, A., Cope, K., Tabesh, A., Clark, J. M., Torbenson, M., … Risby, T. H. (2006). Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations. Biomarkers, 11(2), 174–183. https://doi.org/10.1080/13547500500421070
Solga, S. F., A. Alkhuraishe, K. Cope, A. Tabesh, J. M. Clark, M. Torbenson, P. Schwartz, T. Magnuson, A. M. Diehl, and T. H. Risby. “Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations.Biomarkers 11, no. 2 (2006): 174–83. https://doi.org/10.1080/13547500500421070.
Solga SF, Alkhuraishe A, Cope K, Tabesh A, Clark JM, Torbenson M, et al. Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations. Biomarkers. 2006;11(2):174–83.
Solga, S. F., et al. “Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations.Biomarkers, vol. 11, no. 2, 2006, pp. 174–83. Pubmed, doi:10.1080/13547500500421070.
Solga SF, Alkhuraishe A, Cope K, Tabesh A, Clark JM, Torbenson M, Schwartz P, Magnuson T, Diehl AM, Risby TH. Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations. Biomarkers. 2006;11(2):174–183.
Journal cover image

Published In

Biomarkers

DOI

ISSN

1354-750X

Publication Date

2006

Volume

11

Issue

2

Start / End Page

174 / 183

Location

England

Related Subject Headings

  • Toxicology
  • Sulfur
  • Middle Aged
  • Male
  • Humans
  • Female
  • Fatty Liver
  • Ethanol
  • Carbon Dioxide
  • Breath Tests