De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant.

Journal Article (Journal Article)

Orthotopic liver transplantation is the only definitive therapeutic option in patients with primary sclerosing cholangitis (PSC) and end-stage liver disease. However, PSC recurs in up to 20% of patients transplanted for this indication. To date, no patient has been reported to develop cholangiocarcinoma (CCA) post-transplant, without biliary tract cancer having been present pretransplant. Here, we report recurrent PSC complicated by de-novo CCA in a 31-year-old man transplanted for PSC 8 years earlier. Cholangiocarcinoma was confirmed using a combination of computed tomography, cholangiography, positron emission tomography and histological examination of biliary cytology. He has since been successfully re-transplanted following preoperative chemo-radiotherapy. No viable tumor was identified in the explanted liver. This case establishes that long-term complications associated with PSC and biliary-enteric surgery such as CCA may become apparent in new grafts post-transplant.

Full Text

Duke Authors

Cited Authors

  • Heneghan, MA; Tuttle-Newhall, JE; Suhocki, PV; Muir, AJ; Morse, M; Bornstein, JD; Sylvestre, PB; Collins, B; Kuo, PC; Rockey, DC

Published Date

  • May 2003

Published In

Volume / Issue

  • 3 / 5

Start / End Page

  • 634 - 638

PubMed ID

  • 12752322

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1034/j.1600-6143.2003.00110.x


  • eng

Conference Location

  • United States