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Prospective correlation of cervicovaginal cytologic and histologic specimens.

Publication ,  Journal Article
Ibrahim, SN; Krigman, HR; Coogan, AC; Wax, TD; Dodd, LG; Bentley, RC; Robboy, SJ; Johnston, WW
Published in: Am J Clin Pathol
September 1996

An effective, prospective, computer-guided method of correlation is reported. The mechanism for identification of cases, comparison of diagnoses, and reconciliation of discrepancies are explained. The results are similar to prior, retrospective, correlation studies. The benefits specific to this unique prospective approach include optimal capture of cases for correlation, minimization of errors before diagnoses are released to clinicians and patients, and internal standardization of diagnostic criteria. Three thousand four hundred and four consecutive paired cervicovaginal cytologies and biopsies were accessioned at the Pathology Department of Duke University Medical Center over a 43-month period. Of these, 481 paired cases (14%) had discordant diagnoses, defined as differing more than one degree of dysplasia or as dysplasia or carcinoma identified by only one modality. Additional evaluation reconciled the diagnostic differences in 35 cases. Eighteen initial diagnostic differences arose from cytologic screening errors, 16 from interpretive errors by staff pathologists, and one from superficial initial histologic sections. The remaining 446 discordances were attributed to sampling differences. The cytologic smear contained the diagnostic lesion in 40% of the cases and the biopsy the remainder, emphasizing the utility of pairing these sampling techniques in patients at risk for dysplasia.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

September 1996

Volume

106

Issue

3

Start / End Page

319 / 324

Location

England

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Dysplasia
  • Statistics as Topic
  • Prospective Studies
  • Pathology
  • Humans
  • Female
  • Diagnostic Errors
  • Cervix Uteri
  • Biopsy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ibrahim, S. N., Krigman, H. R., Coogan, A. C., Wax, T. D., Dodd, L. G., Bentley, R. C., … Johnston, W. W. (1996). Prospective correlation of cervicovaginal cytologic and histologic specimens. Am J Clin Pathol, 106(3), 319–324. https://doi.org/10.1093/ajcp/106.3.319
Ibrahim, S. N., H. R. Krigman, A. C. Coogan, T. D. Wax, L. G. Dodd, R. C. Bentley, S. J. Robboy, and W. W. Johnston. “Prospective correlation of cervicovaginal cytologic and histologic specimens.Am J Clin Pathol 106, no. 3 (September 1996): 319–24. https://doi.org/10.1093/ajcp/106.3.319.
Ibrahim SN, Krigman HR, Coogan AC, Wax TD, Dodd LG, Bentley RC, et al. Prospective correlation of cervicovaginal cytologic and histologic specimens. Am J Clin Pathol. 1996 Sep;106(3):319–24.
Ibrahim, S. N., et al. “Prospective correlation of cervicovaginal cytologic and histologic specimens.Am J Clin Pathol, vol. 106, no. 3, Sept. 1996, pp. 319–24. Pubmed, doi:10.1093/ajcp/106.3.319.
Ibrahim SN, Krigman HR, Coogan AC, Wax TD, Dodd LG, Bentley RC, Robboy SJ, Johnston WW. Prospective correlation of cervicovaginal cytologic and histologic specimens. Am J Clin Pathol. 1996 Sep;106(3):319–324.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

September 1996

Volume

106

Issue

3

Start / End Page

319 / 324

Location

England

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Dysplasia
  • Statistics as Topic
  • Prospective Studies
  • Pathology
  • Humans
  • Female
  • Diagnostic Errors
  • Cervix Uteri
  • Biopsy