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Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.

Publication ,  Journal Article
Sporrong, B; Falkmer, S; Robboy, SJ; Alumets, J; Håkanson, R; Ljungberg, O; Sundler, F
Published in: Cancer
January 1, 1982

Eighty-one primary ovarian carcinoids and intraovarian metastases from six mid-gut carcinoids were examined for the presence of tumor cells immunoreactive with antisera raised against various neurohormonal peptides, mostly of gastroenteropancreatic (GEP) origin. Twenty of the primary and two of the metastatic carcinoids contained such tumor cells. The incidence of tumors with any kind of neurohormonal peptide immunoreactive tumor cells was 53% in the trabecular carcinoids, and 42% in the strumal carcinoids, whereas the incidence was much lower (7%) in the insular type. Immunoreactive pancreatic polypeptide (PP), glucagon, enkephalin, and somatostatin were those neurohormonal peptides most commonly observed in the tumor cells of the primary carcinoids. Those less commonly found were substance P, calcitonin, VIP, neurotensin, beta-endorphin, and ACTH. Four metastatic carcinoids were nonreactive with all the antisera used. Cells storing immunoreactive insulin, glucagon, PP, VIP, gastrin, substance P, or enkephalin were found in one of the two remaining metastatic carcinoids; in the other only gastrin-immunoreactive tumor cells were observed. The occurrence and distribution of tumor cells storing the neurohormonal peptides in ovarian carcinoids are discussed in relation to their possible origin in the ovary and to carcinoids in the gut.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

January 1, 1982

Volume

49

Issue

1

Start / End Page

68 / 74

Location

United States

Related Subject Headings

  • Somatostatin
  • Pancreatic Polypeptide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neurotensin
  • Intestinal Neoplasms
  • Immunoenzyme Techniques
  • Humans
  • Histocytochemistry
  • Glucagon
 

Citation

APA
Chicago
ICMJE
MLA
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Sporrong, B., Falkmer, S., Robboy, S. J., Alumets, J., Håkanson, R., Ljungberg, O., & Sundler, F. (1982). Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer, 49(1), 68–74. https://doi.org/10.1002/1097-0142(19820101)49:1<68::aid-cncr2820490115>3.0.co;2-#
Sporrong, B., S. Falkmer, S. J. Robboy, J. Alumets, R. Håkanson, O. Ljungberg, and F. Sundler. “Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.Cancer 49, no. 1 (January 1, 1982): 68–74. https://doi.org/10.1002/1097-0142(19820101)49:1<68::aid-cncr2820490115>3.0.co;2-#.
Sporrong B, Falkmer S, Robboy SJ, Alumets J, Håkanson R, Ljungberg O, et al. Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer. 1982 Jan 1;49(1):68–74.
Sporrong, B., et al. “Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids.Cancer, vol. 49, no. 1, Jan. 1982, pp. 68–74. Pubmed, doi:10.1002/1097-0142(19820101)49:1<68::aid-cncr2820490115>3.0.co;2-#.
Sporrong B, Falkmer S, Robboy SJ, Alumets J, Håkanson R, Ljungberg O, Sundler F. Neurohormonal peptides in ovarian carcinoids: an immunohistochemical study of 81 primary carcinoids and of intraovarian metastases from six mid-gut carcinoids. Cancer. 1982 Jan 1;49(1):68–74.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

January 1, 1982

Volume

49

Issue

1

Start / End Page

68 / 74

Location

United States

Related Subject Headings

  • Somatostatin
  • Pancreatic Polypeptide
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neurotensin
  • Intestinal Neoplasms
  • Immunoenzyme Techniques
  • Humans
  • Histocytochemistry
  • Glucagon