Nuclear DNA content of clear cell adenocarcinoma of the vagina and cervix and its relationship to prognosis.

Journal Article (Journal Article)

A study was performed to determine if ploidy levels of nuclear DNA content could be used as a prognostic index of the biologic behavior of clear cell adenocarcinoma of the vagina and cervix in young females. Forty tumors were examined. Four patterns of nuclear DNA distribution were identified: (1) peridiploid stem cell lines (2N to 3N); (2) peritetraploid stem cell lines (3N to 5N); (3) hypertetraploid stem cell lines (greater than 5N); and (4) highly aneuploid without detectable stem cell lines. Tumors having peridiploid and peritetraploid stem cell lines (low ploidy group) were most often clinical Stage I or II (87%) and were in general associated with a favorable prognosis. Tumors having hypertetraploid stem cell lines and highly aneuploid distribution (high ploidy group) were usually clinical Stage III or IV (65%). Clinically advanced tumors (Stage III or IV) had poor prognosis irrespective of ploidy level. Among the clinical Stage I and II tumors, the low ploidy group had a slightly better prognosis than the high ploidy group. This difference, however, was not statistically significant.

Full Text

Duke Authors

Cited Authors

  • Welch, WR; Fu, YS; Robboy, SJ; Herbst, AL

Published Date

  • April 1, 1983

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 230 - 238

PubMed ID

  • 6832636

International Standard Serial Number (ISSN)

  • 0090-8258

Digital Object Identifier (DOI)

  • 10.1016/0090-8258(83)90079-3


  • eng

Conference Location

  • United States