Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas.

Journal Article (Journal Article)

Fifty-four cervical condylomatous lesions, with and without nuclear atypia, from 42 women, were studied with the Feulgen microspectrophotometric technique for nuclear DNA quantitation and an immunoperoxidase technique for human papillomavirus (HPV) antigen. All ordinary cervical condylomas (without atypia/dysplasia) had a diploid or polyploid nuclear DNA distribution; 61% had detectable HPV antigen. Among the cervical condylomas with atypia/dysplasia, 55% (17/31) had diploid or polyploid nuclear DNA pattern, and, of these, 59% (10/17) had demonstrable papillomavirus antigen. Fourteen (45%) were aneuploid lesions, 2 of which had a small number of cells with papillomavirus antigen (14%). These findings suggest that the majority of cervical condylomas are related to papillomavirus infection. That lesions with dysplasia, including high degrees of dysplasia, may also exhibit coexistence of papillomavirus infection suggests the possibility of an infectious etiology in the genesis of cervical squamous neoplasia.

Full Text

Duke Authors

Cited Authors

  • Fu, YS; Braun, L; Shah, KV; Lawrence, WD; Robboy, SJ

Published Date

  • November 1, 1983

Published In

Volume / Issue

  • 52 / 9

Start / End Page

  • 1705 - 1711

PubMed ID

  • 6193864

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19831101)52:9<1705::aid-cncr2820520926>3.0.co;2-d


  • eng

Conference Location

  • United States