Structural anomalies of the cervix and vagina in women enrolled in the Diethylstilbestrol Adenosis (DESAD) Project.
Published
Journal Article
Among women exposed in utero to diethylstilbestrol (DES) and enrolled in the Diethylstilbestrol Adenosis (DESAD) Project, structural anomalies of the cervix or vagina were found in 25% of the 1,655 subjects identified by review of prenatal records, 43% of the 800 who themselves requested entry into the project, and 49% of the 1,089 referred by physicians but in only 2% of the 963 control subjects. Among the 367 cases found by record review to have complete information on the DES exposure, multivariate analysis indicated close association of the anomalies with the gestational week of first exposure and the total dose. Also, the prevalence rate of the anomalies was lower among subjects who had been pregnant and higher among those with later age at menarche.
Full Text
Duke Authors
Cited Authors
- Jefferies, JA; Robboy, SJ; O'Brien, PC; Bergstralh, EJ; Labarthe, DR; Barnes, AB; Noller, KL; Hatab, PA; Kaufman, RH; Townsend, DE
Published Date
- January 1, 1984
Published In
Volume / Issue
- 148 / 1
Start / End Page
- 59 - 66
PubMed ID
- 6691382
Pubmed Central ID
- 6691382
International Standard Serial Number (ISSN)
- 0002-9378
Digital Object Identifier (DOI)
- 10.1016/s0002-9378(84)80033-2
Language
- eng
Conference Location
- United States